Internal carotid artery dissection in a patient with hemophilia A: a case report and literature review.

Autor: Iacono S; Section of Neurology, Department of Biomedicine, Neuroscience, and Advanced Diagnostics (BiND), University of Palermo, 90121, Palermo, Italy., Baschi R; Section of Neurology, Department of Biomedicine, Neuroscience, and Advanced Diagnostics (BiND), University of Palermo, 90121, Palermo, Italy., Di Giorgi L; Section of Neurology, Department of Biomedicine, Neuroscience, and Advanced Diagnostics (BiND), University of Palermo, 90121, Palermo, Italy., Gagliardo C; Section of Radiology, Department of Biomedicine, Neuroscience, and Advanced Diagnostics (BiND), University of Palermo, 90121, Palermo, Italy., Pezzini A; Department of Clinical and Experimental Sciences, University of Brescia, 25123, Brescia, Italy., Monastero R; Section of Neurology, Department of Biomedicine, Neuroscience, and Advanced Diagnostics (BiND), University of Palermo, 90121, Palermo, Italy. roberto.monastero@unipa.it.
Jazyk: angličtina
Zdroj: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology [Neurol Sci] 2023 May; Vol. 44 (5), pp. 1765-1768. Date of Electronic Publication: 2023 Feb 16.
DOI: 10.1007/s10072-023-06671-6
Abstrakt: Spontaneous cervical artery dissection (sCeAD) is the most common cause of ischemic stroke at a young age, but its pathogenetic mechanism and risk factors are not fully elucidated. It is reasonable to think that bleeding propensity, vascular risk factors such as hypertension and head or neck trauma, and constitutional weakness of the arterial wall together play a role in the pathogenesis of sCeAD. Hemophilia A is known to be an X-linked condition that leads to spontaneous bleeding in various tissues and organs. To date, a few cases of acute arterial dissection in patients with hemophilia have been reported, but the relationship between these two diseases has not been studied so far. In addition, there are no guidelines indicating the best antithrombotic treatment option in these patients. We report the case of a man with hemophilia A who developed sCeAD and transient oculo-pyramidal syndrome and was treated with acetylsalicylic acid. We also review previous published cases of arterial dissection in patients with hemophilia, discussing the potential pathogenetic mechanism underlying this rare association and potential antithrombotic therapeutic options.
(© 2023. Fondazione Società Italiana di Neurologia.)
Databáze: MEDLINE
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