Evaluation of a Hospitalized Pediatric COVID-19 Cohort from Indian National Clinical Registry of COVID-19.

Autor: Turuk A; Clinical Studies, Trials and Projection Unit, Indian Council of Medical Research, New Delhi, India., Kumar G; Clinical Studies, Trials and Projection Unit, Indian Council of Medical Research, New Delhi, India., Mukherjee A; Clinical Studies, Trials and Projection Unit, Indian Council of Medical Research, New Delhi, India. aparna.sinha.deb@gmail.com., Jayashree M; Department of Pediatrics, Postgraduate Institute of Medical Education & Research, Chandigarh, India., Patel SM; Department of Pediatrics, Smt. NHL Municipal Medical College, Ahmedabad, Gujarat, India., Bhardwaj P; Department of Community Medicine, All Indian Institute of Medical Sciences, Jodhpur, Rajasthan, India., Bingi TC; Department of Internal Medicine, Gandhi Medical College, Secunderabad, Telangana, India., Baruah TD; Department of Surgery, All Indian Institute of Medical Sciences, Raipur, Chhattisgarh, India., Sharma LK; Bio-Medical Informatics, Indian Council of Medical Research, New Delhi, India., Menon GR; National Institute of Medical Statistics, Indian Council of Medical Research, Delhi, India., Sahu D; National Institute of Medical Statistics, Indian Council of Medical Research, Delhi, India., Panda S; Indian Council of Medical Research, New Delhi, India., Rao VV; National Institute of Medical Statistics, Indian Council of Medical Research, Delhi, India., Bhargava B; Indian Council of Medical Research, New Delhi, India.
Jazyk: angličtina
Zdroj: Indian journal of pediatrics [Indian J Pediatr] 2023 Oct; Vol. 90 (10), pp. 1000-1007. Date of Electronic Publication: 2023 Feb 16.
DOI: 10.1007/s12098-022-04449-w
Abstrakt: Objective: To evaluate the factors associated with mortality of a multicentric cohort of hospitalized COVID-19 patients, 0-18 y old, from 42 centers across India.
Methods: The National Clinical Registry for COVID-19 (NCRC) is an on-going prospective data collection platform enrolling COVID-19 patients diagnosed by real-time PCR or rapid antigen test. The data are collected in prestructured e-capture forms. The sociodemographic, clinical, laboratory, and hospital outcome data from 1 st September 2020 to 20 th February 2022 were analyzed.
Results: Of the 1244 enrolled hospitalized COVID-19 patients aged 0-18 y, 98 and 124 were infants and neonates, respectively. Only 68.6% children were symptomatic at admission, with fever being the most common symptom. Diarrhea, rash, and neurological symptoms were also noted. At least 1 comorbidity was present in 260 (21%) children. The in-hospital mortality rate was 6.2% (n = 67), the highest in infants (12.5%). Altered sensorium (aOR: 6.8, CI: 1.9, 24.6), WHO ordinal scale ≥ 4 at admission (aOR: 19.6, CI: 8.0, 47.8), and malignancy (aOR: 8.9, 95% CI: 2.4, 32.3) were associated with higher odds of death. Malnutrition did not affect the outcome. Mortality rates were similar across the three waves of the pandemic, though a significant shift towards the under-five group was observed in the third wave.
Conclusion: This multicentric cohort of admitted Indian children showed that the COVID-19 was milder in children than adults, and the pattern was consistent across all waves of the pandemic.
(© 2023. The Author(s), under exclusive licence to Dr. K C Chaudhuri Foundation.)
Databáze: MEDLINE
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