The efficacy of honey or olive oil on the severity of oral mucositis and pain compared to placebo (standard care) in children with leukemia receiving intensive chemotherapy: A randomized controlled trial (RCT).

Autor: Badr LK; Professor, American University of Beirut, Riad El Solh, PO Box: 11 0236, Beirut 1107 2020, Lebanon. Electronic address: lb24@aub.edu.lb., El Asmar R; Clinical Nurse Specialist, Oncology, American University of Beirut Medical center Riad El Solh, PO Box: 11 0236, Beirut 1107 2020, Lebanon. Electronic address: re12@aub.edu.lb., Hakim S; Clinical Educator-Clinical and Professional development Center, American University of Beirut Medical Center, Riad El Solh, PO Box: 11 0236, Beirut 1107 2020, Lebanon., Saad R; Clinical nurse specialist, American University of Beirut, Hariri School of Nursing, Riad El Solh, PO Box: 11 0236, Beirut 1107 2020, Lebanon., Merhi R; American University of Beirut Medical center, Riad El Solh, PO Box: 11 0236, Beirut, 1107 2020, Lebanon., Zahreddine A; Case Manager, Hematology, American University of Beirut Medical center Riad El Solh, PO Box: 11 0236, Beirut 1107 2020, Lebanon. Electronic address: az27@aub.edu.lb., Muwakkit S; Professor of Clinical Specialty, American University Of Beirut Medical center, Riad El Solh, PO Box: 11 0236, Beirut 1107 2020, Lebanon. Electronic address: sm03@aub.edu.lb.
Jazyk: angličtina
Zdroj: Journal of pediatric nursing [J Pediatr Nurs] 2023 May-Jun; Vol. 70, pp. e48-e53. Date of Electronic Publication: 2023 Feb 13.
DOI: 10.1016/j.pedn.2022.12.003
Abstrakt: Background: Oral mucositis (OM) is a significant complication occurring in approximately 40 to 80% of patients receiving chemotherapy regimens. Although a wide variety of agents have been tested to prevent OM or reduce its severity, none have provided conclusive evidence.
Objectives: To determine the efficacy of honey or olive oil on the severity and OM pain in children with leukemia and suffering from OM compared to placebo (standard care) and, to assess which of the two interventions is more beneficial.
Methods: A single blind randomized controlled study (RCT) was used to evaluate the effect of Manuka honey or olive oil, in the treatment of chemotherapy-related OM in 42 children with leukemia. The primary outcome was the severity of mucositis, using the World Health Organization (WHO) scale and the secondary outcome was the pain assessed using the Visual analogue scale (VAS).
Results: Children who received the honey had less severe OM (assessed on the (WHO) scale), p = 0.00 and less pain (assessed on the VAS scale), p = 0.00, compared to the control group. Children who received the olive oil had less pain than the control group, p = 0.00), although not lower than the honey group.
Conclusion: Manuka honey or olive oil can be used as alternative therapies by nurses to children with leukemia and suffering from OM, especially in low and middle-income countries where more expensive therapies may not be available or economical.
Practice Implications: Pediatric nurses may recommend Manuka honey to treat OM in children with leukemia as it is safe and inexpensive compared to other treatment modalities.
Competing Interests: Conflict of interest The authors of this study certify that they have no affiliations with, or involvement in, any organization or entity with any financial interest or nonfinancial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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