Capers with caspases: Toxoplasma gondii tales of inflammation and survival.

Autor: Matsuno SY; Department of Molecular Biology & Biochemistry, University of California, Irvine, Irvine, CA 92617 USA., Pandori WJ; Department of Molecular Biology & Biochemistry, University of California, Irvine, Irvine, CA 92617 USA., Lodoen MB; Department of Molecular Biology & Biochemistry, University of California, Irvine, Irvine, CA 92617 USA. Electronic address: mlodoen@uci.edu.
Jazyk: angličtina
Zdroj: Current opinion in microbiology [Curr Opin Microbiol] 2023 Apr; Vol. 72, pp. 102264. Date of Electronic Publication: 2023 Feb 13.
DOI: 10.1016/j.mib.2023.102264
Abstrakt: Intracellular pathogens strike a delicate balance between maintaining their survival within infected cells, while also activating host defense mechanisms. Toxoplasma gondii is a protozoan parasite that initiates a variety of host signaling pathways as it invades host cells and establishes residence in a parasitophorous vacuole. Recent work has highlighted the interplay between T. gondii infection and innate immune pathways that lead to inflammation, several of which converge on caspases. This family of cysteine proteases function at the crossroads of inflammation and cell death and serve as a key target for parasite manipulation. This review focuses on the interaction of T. gondii with caspase-dependent inflammatory and cell death pathways and the role of parasite effector proteins in modulating these processes.
(Copyright © 2023. Published by Elsevier Ltd.)
Databáze: MEDLINE
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