Neuronal dynamics of the default mode network and anterior insular cortex: Intrinsic properties and modulation by salient stimuli.

Autor:	Chao TH; Center for Animal MRI, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Neurology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Lee B; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA., Hsu LM; Center for Animal MRI, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Neurology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Cerri DH; Center for Animal MRI, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Neurology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Zhang WT; Center for Animal MRI, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Neurology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Wang TW; Center for Animal MRI, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Ryali S; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA., Menon V; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.; Wu Tsai Neuroscience Institute, Stanford University, Stanford, CA, USA., Shih YI; Center for Animal MRI, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Neurology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Jazyk:	angličtina
Zdroj:	Science advances [Sci Adv] 2023 Feb 15; Vol. 9 (7), pp. eade5732. Date of Electronic Publication: 2023 Feb 15.
DOI:	10.1126/sciadv.ade5732
Abstrakt:	The default mode network (DMN) is critical for self-referential mental processes, and its dysfunction is implicated in many neuropsychiatric disorders. However, the neurophysiological properties and task-based functional organization of the rodent DMN are poorly understood, limiting its translational utility. Here, we combine fiber photometry with functional magnetic resonance imaging (fMRI) and computational modeling to characterize dynamics of putative rat DMN nodes and their interactions with the anterior insular cortex (AI) of the salience network. Our analysis revealed neuronal activity changes in AI and DMN nodes preceding fMRI-derived DMN activations and cyclical transitions between brain network states. Furthermore, we demonstrate that salient oddball stimuli suppress the DMN and enhance AI neuronal activity and that the AI causally inhibits the retrosplenial cortex, a prominent DMN node. These findings elucidate the neurophysiological foundations of the rodent DMN, its spatiotemporal dynamical properties, and modulation by salient stimuli, paving the way for future translational studies.
Databáze:	MEDLINE
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