GDF-15 and soluble ST2 as biomarkers of right ventricular dysfunction in pulmonary hypertension.

Autor:	Keranov S; Department of Cardiology & Angiology, University of Giessen, Giessen, 35392, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site RheinMain, Bad Nauheim, 61231, Germany., Widmann L; Department of Cardiology & Angiology, University of Giessen, Giessen, 35392, Germany., Jafari L; Department of Cardiology, Kerckhoff Heart & Lung Center, Bad Nauheim, 61231, Germany., Liebetrau C; Cardioangiological Center Bethanien (CCB), Frankfurt, 60389, Germany., Keller T; Department of Cardiology & Angiology, University of Giessen, Giessen, 35392, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site RheinMain, Bad Nauheim, 61231, Germany.; Department of Cardiology, Kerckhoff Heart & Lung Center, Bad Nauheim, 61231, Germany., Troidl C; German Center for Cardiovascular Research (DZHK), Partner Site RheinMain, Bad Nauheim, 61231, Germany.; Department of Cardiology, Kerckhoff Heart & Lung Center, Bad Nauheim, 61231, Germany., Kriechbaum S; German Center for Cardiovascular Research (DZHK), Partner Site RheinMain, Bad Nauheim, 61231, Germany.; Department of Cardiology, Kerckhoff Heart & Lung Center, Bad Nauheim, 61231, Germany., Voss S; German Center for Cardiovascular Research (DZHK), Partner Site RheinMain, Bad Nauheim, 61231, Germany.; Department of Cardiology, Kerckhoff Heart & Lung Center, Bad Nauheim, 61231, Germany., Bauer P; Department of Cardiology & Angiology, University of Giessen, Giessen, 35392, Germany., Richter MJ; Department of Internal Medicine, Justus Liebig University Giessen, Universities of Giessen & Marburg Lung Center (UGMLC), Institute for Lung Health (ILH), Cardio-Pulmonary Institute (CPI), Member of the German Center for Lung Research (DZL), Giessen, 35392, Germany., Tello K; Department of Internal Medicine, Justus Liebig University Giessen, Universities of Giessen & Marburg Lung Center (UGMLC), Institute for Lung Health (ILH), Cardio-Pulmonary Institute (CPI), Member of the German Center for Lung Research (DZL), Giessen, 35392, Germany., Gall H; Department of Internal Medicine, Justus Liebig University Giessen, Universities of Giessen & Marburg Lung Center (UGMLC), Institute for Lung Health (ILH), Cardio-Pulmonary Institute (CPI), Member of the German Center for Lung Research (DZL), Giessen, 35392, Germany., Ghofrani HA; Department of Internal Medicine, Justus Liebig University Giessen, Universities of Giessen & Marburg Lung Center (UGMLC), Institute for Lung Health (ILH), Cardio-Pulmonary Institute (CPI), Member of the German Center for Lung Research (DZL), Giessen, 35392, Germany., Wiedenroth CB; Department of Thoracic Surgery, Kerckhoff Heart & Lung Center, Bad Nauheim, 61231, Germany., Guth S; Department of Thoracic Surgery, Kerckhoff Heart & Lung Center, Bad Nauheim, 61231, Germany., Seeger W; Department of Internal Medicine, Justus Liebig University Giessen, Universities of Giessen & Marburg Lung Center (UGMLC), Institute for Lung Health (ILH), Cardio-Pulmonary Institute (CPI), Member of the German Center for Lung Research (DZL), Giessen, 35392, Germany., Hamm CW; Department of Cardiology & Angiology, University of Giessen, Giessen, 35392, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site RheinMain, Bad Nauheim, 61231, Germany.; Department of Cardiology, Kerckhoff Heart & Lung Center, Bad Nauheim, 61231, Germany., Nef H; Department of Cardiology & Angiology, University of Giessen, Giessen, 35392, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site RheinMain, Bad Nauheim, 61231, Germany., Dörr O; Department of Cardiology & Angiology, University of Giessen, Giessen, 35392, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site RheinMain, Bad Nauheim, 61231, Germany.
Jazyk:	angličtina
Zdroj:	Biomarkers in medicine [Biomark Med] 2022 Dec; Vol. 16 (17), pp. 1193-1207. Date of Electronic Publication: 2023 Feb 15.
DOI:	10.2217/bmm-2022-0395
Abstrakt:	Background: This study analyzed the utility of soluble ST2 (sST2) and GDF-15 as biomarkers of right ventricular (RV) function in patients with pulmonary hypertension (PH). Methods: GDF-15 and sST2 serum concentrations were measured in patients with PH (n = 628), dilated cardiomyopathy (n = 31) and left ventricular hypertrophy (n = 47), and in healthy controls (n = 61). Results: Median sST2 and GDF-15 levels in patients with left ventricular hypertrophy were higher than in patients with PH and dilated cardiomyopathy. In tertile analysis GDF-15 >1363 pg/ml and sST2 >38 ng/ml were associated with higher N-terminal pro-brain natriuretic peptide, RV systolic dysfunction, RV-pulmonary arterial uncoupling and hemodynamic impairment. Conclusion: GDF-15 and sST2 are potential biomarkers of RV dysfunction in patients with PH.
Databáze:	MEDLINE
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