Relationship Between Maternal Serum Cortisol and Maternal Insulin Resistance and Fetal Ultrasound Characteristics in Gestational Diabetes Mellitus.

Autor:	Tien Nguyen S; Department of Rheumatology and Endocrinology, Military Hospital 103, Vietnam Military Medical University, Ha Noi, Vietnam., Bui Minh T; Department of Obstetrics and Gynecology, Thai Binh University of Medicine and Pharmacy, Thai Binh, Vietnam., Trung Dinh H; Department of Requested Treatment, National Hospital of Endocrinology, Ha Noi, Vietnam.; National Hospital of Endocrinology, Ha Noi, Vietnam., Dinh Le T; Department of Rheumatology and Endocrinology, Military Hospital 103, Vietnam Military Medical University, Ha Noi, Vietnam., Phi Thi Nguyen N; Department of Rheumatology and Endocrinology, Military Hospital 103, Vietnam Military Medical University, Ha Noi, Vietnam., Tran TTH; Department of Requested Treatment, National Hospital of Endocrinology, Ha Noi, Vietnam., Hien Vu T; Department of Requested Treatment, National Hospital of Endocrinology, Ha Noi, Vietnam., Luong Cong T; Cardiovascular Center, Military Hospital 103, Vietnam Medical Military University, Ha Noi, Vietnam., Ho Thi Nguyen L; Department of Requested Treatment, National Hospital of Endocrinology, Ha Noi, Vietnam., Tuan Pham P; Department of Requested Treatment, National Hospital of Endocrinology, Ha Noi, Vietnam.; National Hospital of Endocrinology, Ha Noi, Vietnam., Viet Tran T; Department of Infectious Diseases, Military Hospital 103, Vietnam Medical Military University, Hanoi, 10000, Vietnam., Xuan Nguyen K; Department of Military Medical Command and Organization, Vietnam Medical Military University, Ha Noi, Vietnam.
Jazyk:	angličtina
Zdroj:	Diabetes, metabolic syndrome and obesity : targets and therapy [Diabetes Metab Syndr Obes] 2023 Feb 08; Vol. 16, pp. 365-372. Date of Electronic Publication: 2023 Feb 08 (Print Publication: 2023).
DOI:	10.2147/DMSO.S400995
Abstrakt:	Introduction: Cortisol is proven to play a crucial role in hyperglycemia and fetal development in gestational diabetes mellitus (GDM). This research aims to investigate the relationship between maternal serum cortisol and insulin resistance indices and fetal ultrasound characteristics in women with GDM. Methods: A cross-sectional and descriptive study on 144 GDM in Vietnam from January 2015 to December 2020. Serum cortisol was measured using electrochemiluminescence immunoassay at 8 a.m. on the examination day in the vicinity of the 24th gestational week. Fetal ultrasound was performed by an experienced person who was blind to the study. Results: The mean cortisol level in the GDM group was 627.04 nmol/L. Serum cortisol levels positively correlated with abdominal circumference (AC), fasting plasma glucose (FPG), insulin, triglycerides, HOMA2-IR, and Mathew indices (with r of 0.18, 0.22, 0.18, 0.17, 0.18, and 0.22, respectively). Serum cortisol levels negatively correlated with QUICKI and McAuley indices (with r of -0.19 and -0.21), respectively. In a univariate linear regression, maternal serum cortisol positively correlated with fetal AC, head circumference (HC), and biparietal diameter (BPD) (with r of 0.21; 0.23; and 0.25, respectively). In a multivariate linear regression analysis, cortisol positively correlated with fetal AC, HC, and BPD after adjusting to maternal McAuley index. Conclusion: Serum cortisol levels in GDM correlated with fasting blood glucose, triglycerides, and insulin resistance. Besides, serum cortisol levels in GDM positively correlated with fetal development. Competing Interests: The authors declared no potential conflicts of interest to this article’s research, authorship, and/or publication. (© 2023 Tien Nguyen et al.)
Databáze:	MEDLINE
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