Effect of monosodium glutamate on fetal development and progesterone level in pregnant Wistar Albino rats.

Autor: Shosha HM; Zoology Department, Faculty of Sciences, Suez Canal University, Ismailia, 41522, Egypt., Ebaid HM; Zoology Department, Faculty of Sciences, Suez Canal University, Ismailia, 41522, Egypt., Toraih EA; Department of Surgery, School of Medicine, Tulane University, New Orleans, LA, USA.; Genetics Unit, Department of Histology and Cell Biology, Faculty of Medicine, Suez Canal University, Ismailia, 41522, Egypt., Abdelrazek HMA; Department of Physiology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, 41522, Egypt., Elrayess RA; Zoology Department, Faculty of Sciences, Suez Canal University, Ismailia, 41522, Egypt. ranwa_elrayess@science.suez.edu.eg.
Jazyk: angličtina
Zdroj: Environmental science and pollution research international [Environ Sci Pollut Res Int] 2023 Apr; Vol. 30 (17), pp. 49779-49797. Date of Electronic Publication: 2023 Feb 14.
DOI: 10.1007/s11356-023-25661-x
Abstrakt: Monosodium glutamate (MSG) is a widespread flavor enhancer and stabilizer in manufactured or packaged foods that possess myriad adverse effects. This study aimed to evaluate the effect of MSG on placental progesterone receptors and fetal development. Thirty pregnant Wistar Albino rats were divided into three groups (ten/each). The control group (G1) gavaged distilled water only, low-dose treated group (G2) gavaged 3 g/kg MSG, and high-dose treated group (G3) gavaged 6 g/kg MSG from 1st to 18th days of gestation, and all pregnant rats were sacrificed on the 19th day of gestation. The effect of MSG on fetal weights, crown vertebral length (CVL), placental weight, placental ghrelin expression, and fetal skeleton examination were estimated. MSG induced a significant decrease in fetal weights, CVL lengths, placental weight, and ghrelin expression in both treatment groups compared to the control group. Several parts of the fetal skeleton showed incomplete ossification and delayed chondrification in which high-dose maternally treated fetuses were more affected. Many degenerative changes were detected in both maternal and fetal liver and kidney tissues in MSG-treated groups. Moreover, MSG caused a significant increase in serum ALT, ALP, and creatinine levels in pregnant rats' blood. Serum progesterone was only elevated in G3 on the 19th day of gestation. This study showed that the administration of MSG during pregnancy adversely influences fetal growth and skeletal development and caused several biochemical and histological changes in the maternal and fetal liver and kidney tissues which assure the toxic and teratogenic effects of MSG.
(© 2023. The Author(s).)
Databáze: MEDLINE
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