Synthesis of 1-[ω-(Bromophenoxy)alkyl]-3-Naphthalenylmethyl Uracil Derivatives and Their Analogues as Probable Inhibitors of Human Cytomegalovirus Replication.

Autor: Paramonova MP; Volgograd State Medical University, Volgograd, Russia., Gureeva ES; Volgograd State Medical University, Volgograd, Russia., Ozerov AA; Volgograd State Medical University, Volgograd, Russia., Snoeck R; Rega Institute for Medical Research, B-3000, Leuven, KU Leuven, Belgium., Andrei G; Rega Institute for Medical Research, B-3000, Leuven, KU Leuven, Belgium., Alexandrov DA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia., Handazinskaya AL; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia. khandazhinskaya@bk.ru., Novikov MS; Volgograd State Medical University, Volgograd, Russia., Kochetkov SN; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
Jazyk: angličtina
Zdroj: Doklady. Biochemistry and biophysics [Dokl Biochem Biophys] 2022 Dec; Vol. 507 (1), pp. 357-362. Date of Electronic Publication: 2023 Feb 14.
DOI: 10.1134/S1607672922340099
Abstrakt: A new series of 1-[ω-(bromophenoxy)alkyl]-uracil derivatives containing naphthalen-1-yl, naphthalen-2-yl, 1-bromonaphthalen-2-ylmethyl, benzyl, and anthracene-9-ylmethyl fragments in position 3 of uracil residue was synthesized. The antiviral properties of the synthesized compounds against human cytomegalovirus were studied. It was found that the compound containing a bridge consisting of five methylene groups exhibits a high anti-cytomegalovirus activity in vitro.
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Databáze: MEDLINE
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