Blood Plasma Lipoproteids: Oxidizability and Participation in the Transport of Acylhydroperoxy-Derivatives of Phospholipids.

Autor: Lankin VZ; National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia. lankin0309@mail.ru., Tikhaze AK; National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia., Kosach VY; National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia., Doroshchuk AD; National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia.
Jazyk: angličtina
Zdroj: Doklady. Biochemistry and biophysics [Dokl Biochem Biophys] 2022 Dec; Vol. 507 (1), pp. 294-297. Date of Electronic Publication: 2023 Feb 14.
DOI: 10.1134/S1607672922060072
Abstrakt: Oxidatively modified plasma lipoproteins play an important role in the molecular mechanisms of vascular wall damage in atherosclerosis and diabetes mellitus. It was found that the oxidizability of low-density lipoproteins (LDLs) is more than one order of magnitude higher than that of high-density lipoproteins (HDLs). It was shown that acylhydroperoxy derivatives of phospholipids of oxidized biomembranes are predominantly captured by LDL particles, but not by HDLs, which refutes the hypothesis about the involvement of HDLs in the reverse transport of lipohydroperoxides (LOOH). The results suggest the possibility of different mechanisms of LOOH accumulation in LDLs: due to the increased oxidizability of LDLs and due to the effective transmembrane transport of LOOH by LDL particles.
(© 2022. Pleiades Publishing, Ltd.)
Databáze: MEDLINE
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