| Autor: |
Vermes I; Department of Clinical Chemistry, H.d.K. Hospital, Oldenzaal, The Netherlands., Steinmetz ET, Zeyen LJ, van der Veen EA |
| Jazyk: |
angličtina |
| Zdroj: |
Diabetologia [Diabetologia] 1987 Jun; Vol. 30 (6), pp. 434-6. |
| DOI: |
10.1007/BF00292548 |
| Abstrakt: |
Erythrocyte and white blood cell suspensions were prepared from 22 Type 1 (insulin-dependent) and 37 Type 2 (non-insulin-dependent) diabetic patients and from 57 control subjects. Cell filterability was studied with the new "St. George's Filtrometer", which can discriminate between cell deformability and filter occlusion. A pronounced increase of filter clogging was found in diabetic patients compared with control subjects. There was no significant difference between Type 1 and Type 2 diabetic patients, but a significantly increased clogging was found in patients with retinopathy compared with retinopathy-free patients. Considering that filter occlusion is mainly due to leucocytes, our results show a reduced filterability of white blood cells in diabetic patients. Altered white blood cell function may act as an additional factor in the impairment of microvascular circulation in diabetic patients. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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