Longitudinal associations of anticholinergic medications on cognition and possible mitigating role of physical activity.

Autor: Norling AM; Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA.; Evelyn F. McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, Alabama, USA., Bennett A; Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA., Crowe M; Department of Psychology, University of Alabama at Birmingham, Birmingham, Alabama, USA., Long DL; Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA., Nolin SA; Department of Psychology, University of Alabama at Birmingham, Birmingham, Alabama, USA., Myers T; Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA.; Evelyn F. McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, Alabama, USA., Del Bene VA; Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA.; Evelyn F. McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, Alabama, USA., Lazar RM; Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA.; Evelyn F. McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, Alabama, USA., Gerstenecker A; Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA.; Evelyn F. McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Jazyk: angličtina
Zdroj: Journal of the American Geriatrics Society [J Am Geriatr Soc] 2023 Jun; Vol. 71 (6), pp. 1937-1943. Date of Electronic Publication: 2023 Feb 14.
DOI: 10.1111/jgs.18279
Abstrakt: Background: Many older adults take at least one prescription medication with anticholinergic (ACH) activity, which can impact the central nervous system and can lead to cognitive decline and impairment especially in an aging population susceptible to cognitive changes. We examined this relationship between ACH burden and cognitive function in middle-aged and older adults. We further determined if increased activity levels mitigated the relationships between ACH burden and cognition.
Methods: Data from The Reasons for Geographic and Racial Differences in Stroke project were used. We included 20,575 adults aged ≥45 years with longitudinal cognitive testing. The anticholinergic cognitive burden (ACB) scale was used to assess for ACH use and overall burden. Cognitive data included an overall composite score, a memory, and verbal fluency composites. Mixed effects models were conducted to determine if cognitive function worsened over time for participants with higher ACB (>3) scores. The full model adjusted for age, sex, race, education, diabetes, hypertension, cardiovascular disease, congestive heart failure, and dyslipidemia, self-reported physical activity (PA) and depressive symptoms.
Results: A significant relationship between ACH burden and composite cognitive scores was found (p = <0.001), with those with higher ACB showing more rapid cognitive decline over time. There was an effect of age for participants with higher ACB (>3) scores and ACB as a continuous variable. Baseline PA level was associated with less cognitive decline over time and this effect was greater in older cohorts.
Conclusions: We observed an effect of ACHs on cognition in adults ≥45 years old that worsened with age. ACH users showed more cognitive effects, whereas PA emerged as a possible mitigating factor.
(© 2023 The Authors. Journal of the American Geriatrics Society published by Wiley Periodicals LLC on behalf of The American Geriatrics Society.)
Databáze: MEDLINE
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