[Microsatellite instability and DNA mismatch repair deficiency detection in tumors of various sites].

Autor:	Raskin GA; Dr. Berezin Medical Institute, St. Petersburg, Russia.; Saint-Petersburg State University, St. Petersburg, Russia., Mukhina MS; Dr. Berezin Medical Institute, St. Petersburg, Russia., Kaurtseva AS; Dr. Berezin Medical Institute, St. Petersburg, Russia., Andreeva YY; Russian Medical Academy of Continuous Professional Education, Moscow, Russia., Zavalishina LE; Russian Medical Academy of Continuous Professional Education, Moscow, Russia., Protasova AE; Saint-Petersburg State University, St. Petersburg, Russia., Orlova RV; Saint-Petersburg State University, St. Petersburg, Russia.
Jazyk:	ruština
Zdroj:	Arkhiv patologii [Arkh Patol] 2023; Vol. 85 (1), pp. 36-42.
DOI:	10.17116/patol20238501136
Abstrakt:	Microsatellite instability, which is caused by a deficiency in the DNA unpaired nucleotide repair system, is an important pathogenetic event for some tumors. In addition, the detection of this molecular feature becomes an independent prognostic factor in the course of the disease and a predictor for the appointment of therapy with immune checkpoint inhibitors. Immunohistochemistry is a reliable and available method for detecting a deficiency in the DNA mismatch repair system, and it has recommended as a screening for hereditary syndromes associated with microsatellite instability. This article discusses the advantages and disadvantages of this research method from the point of view of the practitioner.
Databáze:	MEDLINE
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