Ictal semiology of gelastic seizures.
Autor: | Mirandola L; Neurology Unit, San Giovanni Bosco Hospital, Turin, Italy. Electronic address: laura.mirandola@aslcittaditorino.it., Cantalupo G; Child Neuropsychiatry Unit, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Verona, Italy; Research Center for Pediatric Epilepsies Verona, Italy., d'Orsi G; Neurology Unit, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo (Fg), Italy; Epilepsy Center - Clinic of Nervous System Disease, Policlinico Riuniti, Foggia, Italy., Meletti S; Division of Neurology, University Hospital of Modena, Modena, Italy; Department of Biomedical, Metabolic and Neural Science, University of Modena and Reggio Emilia, Modena, Italy., Vaudano AE; Division of Neurology, University Hospital of Modena, Modena, Italy; Department of Biomedical, Metabolic and Neural Science, University of Modena and Reggio Emilia, Modena, Italy., Di Vito L; IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy., Vignoli A; Childhood and Adolescence Neurology and Psychiatry Unit, Niguarda Hospital Department of Health Sciences, University of Milan, Milan, Italy; Epilepsy Center-Child Neuropsychiatric Unit, ASST Santi Paolo e Carlo, Milan, Italy., Tassi L; 'Claudio Munari' Epilepsy Surgery Center, Niguarda Hospital, Milan, Italy., Pelliccia V; 'Claudio Munari' Epilepsy Surgery Center, Niguarda Hospital, Milan, Italy. |
---|---|
Jazyk: | angličtina |
Zdroj: | Epilepsy & behavior : E&B [Epilepsy Behav] 2023 Mar; Vol. 140, pp. 109025. Date of Electronic Publication: 2023 Feb 11. |
DOI: | 10.1016/j.yebeh.2022.109025 |
Abstrakt: | Gelastic seizures are rare epileptic manifestations characterized by laughter or a smile. The main etiology is represented by hypothalamic hamartoma, but also focal localization of the epileptogenic zone is described. We reviewed a group of patients with gelastic seizures to describe the semiology and to establish any difference related to diverse epilepsy etiologies. Thirty-five seizures from 16 patients (6 females) were reviewed. The study confirms that hypothalamic hamartoma is the more frequent etiology associated with gelastic seizures. Laughter represented the majority of gelastic ictal signs, while the ictal smile was less frequent. In 87.5% of patients, the manifestation of laughter or smile was the only ictal phenomenon, or the first and the most important clinical sign. Interestingly, it has been observed that patients with a lesion localized in the hypothalamic region had more frequently laughter with emotional involvement and that laughter was the only manifestation of the seizure. On the contrary, patients with lesions localized outside the hypothalamic region had more often seizures with laugh without emotional involvement, resembling a more mechanical action, and associated with other semeiological signs. It, therefore, seems possible to assume that the emotional involvement and the expression of mirth during the seizure, especially in children, are more frequently associated with hypothalamic hamartoma. On the contrary, when the semiology includes less conveyed emotion similar to a mechanical action and other symptoms, an extra hypothalamic localization should be considered. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2022 Elsevier Inc. All rights reserved.) |
Databáze: | MEDLINE |
Externí odkaz: |