Oral Contraceptive Pills Are an Effective Method of Preventing Pregnancy in Women With Crohn's Disease.

Autor:	Daoud ND; Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, Florida, USA., Ghoz H; Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, Florida, USA., Cannon R; Department of Obstetrics and Gynecology, Boston Medical Center, Boston, Massachusetts, USA., Farraye JA; Department of Obstetrics and Gynecology, Boston Medical Center, Boston, Massachusetts, USA., Picco MF; Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, Florida, USA., Kane SV; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA., Kochhar GS; Department of Gastroenterology, Hepatology and Nutrition, Allegheny Health Network, Pittsburgh, Pennsylvania, USA., Woodhams EJ; Department of Obstetrics and Gynecology, Boston Medical Center, Boston, Massachusetts, USA., Farraye FA; Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, Florida, USA.
Jazyk:	angličtina
Zdroj:	Crohn's & colitis 360 [Crohns Colitis 360] 2021 Nov 13; Vol. 4 (1), pp. otab078. Date of Electronic Publication: 2021 Nov 13 (Print Publication: 2022).
DOI:	10.1093/crocol/otab078
Abstrakt:	Background: Oral contraceptive pill (OCP) use in the general population is associated with a failure rate as low as 0.3% with perfect use but as high as 9% with typical use. Women with Crohn's disease (CD) may have malabsorption in the setting of small bowel disease or resection, which could affect absorption of OCPs. Our aim was to determine the incidence of pregnancy in women with CD on OCPs. Methods: This is a retrospective study assessing the incidence rate of OCP failure in females between 18 and 45 years of age seen at the Mayo Clinic with a diagnosis of CD and provided a prescription for OCPs, between 2016 and 2020. Failure was defined as clear documentation of becoming pregnant while using OCPs or having an active prescription of OCP at the time of conception. Results: A total of 818 female patients with CD between 18 and 45 years of age with a prescription for an OCP were included in our study. Sixty-six patients (8%) conceived in this cohort. Of the 66 patients who became pregnant, 57 stopped the OCP before conceiving, 5 were excluded due to lack of data, and 4 women had active oral contraceptive prescriptions when they became pregnant (pregnancy rate of 0.5%). Conclusions: In female patients with CD who are using OCPs for contraception, we found a low rate of pregnancy (0.5%) similar to the rate of pregnancy with perfect use of OCPs in the general population. OCPs are an effective method of birth control in women with CD. (© The Author(s) 2021. Published by Oxford University Press on behalf of Crohn's & Colitis Foundation.)
Databáze:	MEDLINE
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