Prevalence and persistence of Neisseria meningitidis carriage in Swedish university students.

Autor:	Olof S; Department of Infectious Diseases, Faculty of Medicine and Health, Örebro University, Örebro, Sweden., Lorraine E; Department of Laboratory Medicine, Clinical Microbiology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden., Berhane A I; Faculty of Medicine and Health, Inflammatory Response and Infection Susceptibility Centre (iRiSC), School of Medical Sciences, Örebro University, Örebro, Sweden., Alexander P; Faculty of Medicine and Health, Inflammatory Response and Infection Susceptibility Centre (iRiSC), School of Medical Sciences, Örebro University, Örebro, Sweden., Anders M; Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, Sweden., Sara TH; Department of Laboratory Medicine, Clinical Microbiology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden., Martin S; Department of Laboratory Medicine, Clinical Microbiology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden., Per O; Department of Laboratory Medicine, Clinical Microbiology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden., Hans F; Department of Laboratory Medicine, Clinical Microbiology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden., Bianca S; Department of Laboratory Medicine, Clinical Microbiology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden., Eva S; Faculty of Medicine and Health, Inflammatory Response and Infection Susceptibility Centre (iRiSC), School of Medical Sciences, Örebro University, Örebro, Sweden., Paula M; Department of Laboratory Medicine, Clinical Microbiology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden., Susanne J; Department of Laboratory Medicine, Clinical Microbiology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Jazyk:	angličtina
Zdroj:	Epidemiology and infection [Epidemiol Infect] 2023 Feb 13; Vol. 151, pp. e25. Date of Electronic Publication: 2023 Feb 13.
DOI:	10.1017/S0950268823000018
Abstrakt:	The bacterium Neisseria meningitidis causes life-threatening disease worldwide, typically with a clinical presentation of sepsis or meningitis, but can be carried asymptomatically as part of the normal human oropharyngeal microbiota. The aim of this study was to examine N. meningitidis carriage with regard to prevalence, risk factors for carriage, distribution of meningococcal lineages and persistence of meningococcal carriage. Throat samples and data from a self-reported questionnaire were obtained from 2744 university students (median age: 23 years) at a university in Sweden on four occasions during a 12-month period. Meningococcal isolates were characterised using whole-genome sequencing. The carriage rate among the students was 9.1% (319/3488; 95% CI 8.2-10.1). Factors associated with higher carriage rate were age ≤22 years, previous tonsillectomy, cigarette smoking, drinking alcohol and attending parties, pubs and clubs. Female gender and sharing a household with children aged 0-9 years were associated with lower carriage. The most frequent genogroups were capsule null locus ( cnl ), group B and group Y and the most commonly identified clonal complexes (cc) were cc198 and cc23. Persistent carriage with the same meningococcal strain for 12 months was observed in two students. Follow-up times exceeding 12 months are recommended for future studies investigating long-term carriage of N. meningitidis .
Databáze:	MEDLINE
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