| Autor: |
Tsopgni WDT; Chemistry Laboratory, Department of Chemistry, Faculty of Science, University of Douala, Douala, Cameroon., Ehawa Essoung FR; University Institute of Technology, University of Ngaoundere, Ngaoundere, Cameroon., Makam Kuetche P; Chemistry Laboratory, Department of Chemistry, Faculty of Science, University of Douala, Douala, Cameroon., Azebaze AGB; Chemistry Laboratory, Department of Chemistry, Faculty of Science, University of Douala, Douala, Cameroon., Ajeck MJ; Department of Chemistry, University of Buea, Faculty of Sciences, Buea, Cameroon., Meli AL; School of Chemical Engineering and Mineral Industries, University of Ngaoundere, Ngaoundere, Cameroon., Sewald N; Organic and Bioorganic Chemistry, Department of Chemistry, Bielefeld University, Bielefeld, Germany., Wansi JD; Chemistry Laboratory, Department of Chemistry, Faculty of Science, University of Douala, Douala, Cameroon., Kamdem Waffo AF; Chemistry Laboratory, Department of Chemistry, Faculty of Science, University of Douala, Douala, Cameroon., Tcho AT; Department of Chemistry, University of Buea, Faculty of Sciences, Buea, Cameroon. |
| Abstrakt: |
The chemical investigation of the methanolic root extract of Flacourtia vogelii led to the isolation of a new arylbenzoate derivative, vogelinal ( 1 ), together with thirteen known compounds ( 2-14 ). The structures of the isolates were elucidated by extensive spectroscopic and spectrometric analyses (1D and 2D NMR, ESI-MS) and by comparison with previously reported data. All the compounds were tested for their antioxidant, antifungal and antibacterial activities. Compound 7 exhibited the highest antioxidant potential, with RSa 50 of 11.80 ± 2.13 µg/mL, RSa 50 of 42.60 ± 6.32 µg/mL and RC 50 of 51.60 ± 7.71 µg/mL for the DPPH, ABTS and FRAP assay, respectively. Compound 13 displayed weak antifungal effect with MIC value of 125 μg/mL against Candida parapsilosis . Compound 8 showed weak antibacterial effect with MIC value of 125 μg/mL, against Shigella dysenteria . The present study, conclude that this species could be a promising source of antioxidant and antibacterial constituents. |
