Evaluating the effect of glidants on tablet sticking propensity of ketoprofen using powder rheology.

Autor: Parekh BV; Arnold and Marine Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, NY, USA; Natoli Institute for Industrial Pharmacy Research and Development, Long Island University, Brooklyn, NY, USA., Saddik JS; Pfizer Inc., Groton, CT, USA., Patel DB; Natoli Scientific, A Division of Natoli Engineer Company, Inc., Telford, PA, USA., Dave RH; Arnold and Marine Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, NY, USA; Natoli Institute for Industrial Pharmacy Research and Development, Long Island University, Brooklyn, NY, USA. Electronic address: rutesh.dave@liu.edu.
Jazyk: angličtina
Zdroj: International journal of pharmaceutics [Int J Pharm] 2023 Mar 25; Vol. 635, pp. 122710. Date of Electronic Publication: 2023 Feb 09.
DOI: 10.1016/j.ijpharm.2023.122710
Abstrakt: Punch sticking has been a leading drawback that has challenged successful tablet manufacturing since its initial conception. Due to the capricious nature of the complication, this can arise during any phase of the development process. Even now, identifying such a problem is a prerequisite during the initial stage of development. The present study evaluated the role of Aerosil®200, talc, and Syloid®244 as glidants in varying amounts ranging from 0.0 percent to 2.0 percent w/w on tablets sticking relatively to five different metal surfaces, with ketoprofen as the model drug. Powder rheology is a predictable technique used to calculate the sticking index. The sticking index of each formulation in comparison to each metal coupon was identified by calculating the kinematic angle of internal friction and the angle of wall friction using the shear cell test and wall friction test, respectively. Interestingly, glidants were found to reduce the sticking propensity of the powder blend in a concentration-dependent manner. In addition, the compression study validated the expected sticking tendency ranking order. According to the research data, the sticking index could effectively be utilized to envisage the possibility of tablet sticking, i.e., by selecting the formulation's excipient and their percentages or selecting appropriate punched metal surfaces in the tableting process.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: