The prognostic value of histopathology in invasive lung adenocarcinoma: a comparative review of the main proposed grading systems.

Autor:	Lucà S; Pathology Unit, Department of Mental and Physical Health and Preventive Medicine, Università degli Studi della Campania 'L. Vanvitelli', Naples, Italy., Zannini G; Pathology Unit, Department of Mental and Physical Health and Preventive Medicine, Università degli Studi della Campania 'L. Vanvitelli', Naples, Italy., Morgillo F; Department of Precision Medicine, Medical Oncology, Università degli Studi della Campania Luigi Vanvitelli, Naples, Italy., Della Corte CM; Department of Precision Medicine, Medical Oncology, Università degli Studi della Campania Luigi Vanvitelli, Naples, Italy., Fiorelli A; Division of Thoracic Surgery, University of Campania 'Luigi Vanvitelli', Piazza Miraglia, 2, 80138, Naples, Italy., Zito Marino F; Pathology Unit, Department of Mental and Physical Health and Preventive Medicine, Università degli Studi della Campania 'L. Vanvitelli', Naples, Italy., Campione S; A. Cardarelli Hospital, Department of Advanced Diagnostic-Therapeutic Technologies and Health Services Section of Anatomic Pathology, Naples, Italy., Vicidomini G; Division of Thoracic Surgery, University of Campania 'Luigi Vanvitelli', Piazza Miraglia, 2, 80138, Naples, Italy., Guggino G; Thoracic Surgery Department, AORN A. Cardarelli Hospital, Naples, Italy., Ronchi A; Pathology Unit, Department of Mental and Physical Health and Preventive Medicine, Università degli Studi della Campania 'L. Vanvitelli', Naples, Italy., Accardo M; Pathology Unit, Department of Mental and Physical Health and Preventive Medicine, Università degli Studi della Campania 'L. Vanvitelli', Naples, Italy., Franco R; Pathology Unit, Department of Mental and Physical Health and Preventive Medicine, Università degli Studi della Campania 'L. Vanvitelli', Naples, Italy.
Jazyk:	angličtina
Zdroj:	Expert review of anticancer therapy [Expert Rev Anticancer Ther] 2023 Mar; Vol. 23 (3), pp. 265-277. Date of Electronic Publication: 2023 Feb 20.
DOI:	10.1080/14737140.2023.2179990
Abstrakt:	Introduction: An accurate histological evaluation of invasive lung adenocarcinoma is essential for a correct clinical and pathological definition of the tumour. Different grading systems have been proposed to predict the prognosis of invasive lung adenocarcinoma. Areas Covered: Invasive non mucinous lung adenocarcinoma is often morphologically heterogeneous, consisting of complex combinations of architectural patterns with different proportions. Several grading systems for non-mucinous lung adenocarcinoma have been proposed, being the main based on architectural differentiation and the predominant growth pattern. Herein we perform a thorough review of the literature using PubMed, Scopus and Web of Science and we highlight the peculiarities and the differences between the main grading systems and compare the data about their prognostic value. In addition, we carried out an evaluation of the proposed grading systems for less common histological variants of lung adenocarcinoma, such as fetal adenocarcinoma and invasive mucinous adenocarcinoma. Expert Opinion: The current IASLC grading system, based on the combined score of predominant growth pattern plus high-grade histological pattern, shows the stronger prognostic significance than the previous grading systems in invasive non mucinous lung adenocarcinoma.
Databáze:	MEDLINE
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