Evaluation of Sustainable Recycled Products to Increase the Production of Nutraceutical and Antibacterial Molecules in Basil Plants by a Combined Metabolomic Approach.

Autor:	Verrillo M; Dipartimento di Agraria, Università di Napoli Federico II, Via Università 100, 80055 Portici, Italy.; Centro Interdipartimentale di Ricerca per la Risonanza Magnetica Nucleare per l'Ambiente, l'Agroalimentare, ed i Nuovi Materiali (CERMANU), Università di Napoli Federico II, Via Università 100, 80055 Portici, Italy., Koellensperger G; Department of Analytical Chemistry, Faculty of Chemistry, University of Vienna, Waehringer Strasse 38, 1090 Vienna, Austria.; Vienna Metabolomics Center (VIME), University of Vienna, Althanstrasse 14, 1090 Vienna, Austria., Puehringer M; Department of Analytical Chemistry, Faculty of Chemistry, University of Vienna, Waehringer Strasse 38, 1090 Vienna, Austria.; Vienna Metabolomics Center (VIME), University of Vienna, Althanstrasse 14, 1090 Vienna, Austria., Cozzolino V; Dipartimento di Agraria, Università di Napoli Federico II, Via Università 100, 80055 Portici, Italy.; Centro Interdipartimentale di Ricerca per la Risonanza Magnetica Nucleare per l'Ambiente, l'Agroalimentare, ed i Nuovi Materiali (CERMANU), Università di Napoli Federico II, Via Università 100, 80055 Portici, Italy., Spaccini R; Dipartimento di Agraria, Università di Napoli Federico II, Via Università 100, 80055 Portici, Italy.; Centro Interdipartimentale di Ricerca per la Risonanza Magnetica Nucleare per l'Ambiente, l'Agroalimentare, ed i Nuovi Materiali (CERMANU), Università di Napoli Federico II, Via Università 100, 80055 Portici, Italy., Rampler E; Department of Analytical Chemistry, Faculty of Chemistry, University of Vienna, Waehringer Strasse 38, 1090 Vienna, Austria.; Vienna Metabolomics Center (VIME), University of Vienna, Althanstrasse 14, 1090 Vienna, Austria.
Jazyk:	angličtina
Zdroj:	Plants (Basel, Switzerland) [Plants (Basel)] 2023 Jan 23; Vol. 12 (3). Date of Electronic Publication: 2023 Jan 23.
DOI:	10.3390/plants12030513
Abstrakt:	Background: An important goal of modern medicine is the development of products deriving from natural sources to improve environmental sustainability. In this study, humic substances (HS) and compost teas (CTs) extracted from artichoke (ART) and coffee grounds (COF) as recycled biomasses were employed on Ocimum basilicum plants to optimize the yield of specific metabolites with nutraceutical and antibacterial features by applying sustainable strategies. Methods: The molecular characteristics of compost derivates were elucidated by Nuclear Magnetic Resonance spectroscopy to investigate the structure-activity relationship between organic extracts and their bioactive potential. Additionally, combined untargeted and targeted metabolomics workflows were applied to plants treated with different concentrations of compost extracts. Results: The substances HS-ART and CT-COF improved both antioxidant activity (TEAC values between 39 and 55 μmol g -1 ) and the antimicrobial efficacy (MIC value between 3.7 and 1.3 μg mL -1 ) of basil metabolites. The metabolomic approach identified about 149 metabolites related to the applied treatments. Targeted metabolite quantification further highlighted the eliciting effect of HS-ART and CT-COF on the synthesis of aromatic amino acids and phenolic compounds for nutraceutical application. Conclusions: The combination of molecular characterization, biological assays, and an advanced metabolomic approach, provided innovative insight into the valorization of recycled biomass to increase the availability of natural compounds employed in the medical field.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu