Rectus Femoris Muscle and Phase Angle as Prognostic Factor for 12-Month Mortality in a Longitudinal Cohort of Patients with Cancer (AnyVida Trial).

Autor:	García-García C; Facultad de Medicina, Universidad of Málaga, 29010 Málaga, Spain.; Unidad de Gestión Clínica en Endocrinología y Nutrición, Hospital Universitario Virgen de la Victoria, 29010 Málaga, Spain., Vegas-Aguilar IM; Unidad de Gestión Clínica en Endocrinología y Nutrición, Hospital Universitario Virgen de la Victoria, 29010 Málaga, Spain.; Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario Virgen de la Victoria, 29010 Málaga, Spain., Rioja-Vázquez R; Unidad de Gestión Clínica en Endocrinología y Nutrición, Hospital Universitario Virgen de la Victoria, 29010 Málaga, Spain.; Asociación de Enfermeras de Nutrición y Dietética (ADENYD), 14004 Córdoba, Spain., Cornejo-Pareja I; Unidad de Gestión Clínica en Endocrinología y Nutrición, Hospital Universitario Virgen de la Victoria, 29010 Málaga, Spain.; Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario Virgen de la Victoria, 29010 Málaga, Spain.; Centro de Investigacion Biomedica en Red de la Fisiopatología de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), 29010 Malaga, Spain., Tinahones FJ; Facultad de Medicina, Universidad of Málaga, 29010 Málaga, Spain.; Unidad de Gestión Clínica en Endocrinología y Nutrición, Hospital Universitario Virgen de la Victoria, 29010 Málaga, Spain.; Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario Virgen de la Victoria, 29010 Málaga, Spain.; Centro de Investigacion Biomedica en Red de la Fisiopatología de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), 29010 Malaga, Spain., García-Almeida JM; Facultad de Medicina, Universidad of Málaga, 29010 Málaga, Spain.; Unidad de Gestión Clínica en Endocrinología y Nutrición, Hospital Universitario Virgen de la Victoria, 29010 Málaga, Spain.; Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario Virgen de la Victoria, 29010 Málaga, Spain.; Centro de Investigacion Biomedica en Red de la Fisiopatología de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), 29010 Malaga, Spain.; Servicio de Endocrinología y Nutrición, Quirónsalud Hospital, 29010 Málaga, Spain.
Jazyk:	angličtina
Zdroj:	Nutrients [Nutrients] 2023 Jan 19; Vol. 15 (3). Date of Electronic Publication: 2023 Jan 19.
DOI:	10.3390/nu15030522
Abstrakt:	Background: Cancer-related malnutrition is still unrecognized and undertreated in clinical practice. The morphofunctional assessment of disease-related malnutrition (DRM) is a new approach that focuses on evaluating changes in body composition and function. The aim of this study is to evaluate the prognostic value of classic and emerging assessment of malnutrition at 12-months survival in cancer patients. Methods: We conducted a prospective study on cancer outpatients. Bioelectrical impedance with phase angle (PhA), nutritional ultrasound by rectus femoris cross-sectional area (RFCSA), hand grip strength, and "Timed Up and Go Test" (TUG) were evaluated as predictors of mortality. Results: Fifty-seven patients were included. The non-survivors had lower PhA values than the survivors (4.7° vs. 5.4°; p < 0.001), and we had the same results with RFCSA 2.98 cm 2 /m 2 vs. 4.27 cm 2 /m 2 ( p = 0.03). Cut-off points were identified using the ROC (receiver operating characteristic) curves for PhA (≤5.6° cancer patients, ≤5.9° men, ≤5.3° women), RFCSA (≤4.47 cm 2 /m 2 cancer patients, ≤4.47° men, ≤2.73° women) and rectus femoris-Y-axis (RF-Y-axis; ≤1.3 cm cancer patients, ≤1.06 men, ≤1 women). In multivariate logistic regression analysis, we found that high PhA was significantly associated with a lower mortality hazard ratio (HR: 0.42 95% CI: 0.21-0.84, p = 0.014). Likewise, high RFCSA was associated with a decrease in mortality risk in the crude model (HR: 0.61 95% CI: 0.39-0.96, p = 0.031). This trend was also maintained in the adjusted models by the confounding variables. Conclusions: Low PhA and RFCSA values are significant independent predictors of mortality in cancer patients. These cut-off points are clinical data that can be used for nutritional assessment and the prediction of clinical outcomes.
Databáze:	MEDLINE
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