| Autor: |
Oubihi A; Laboratory of Natural Resources and Sustainable Development, Faculty of Science, University Ibn Tofail, Kenitra B.P 242, Morocco., Ballaoui FZ; Pharmacodynamy Research Team ERP, Laboratory of Pharmacology and Toxicology, Faculty of Medicine and Pharmacy, University Mohammed V, Rabat B.P: 8007.N.U, Morocco., Imtara H; Faculty of Arts and Sciences, Arab American University Palestine, Jenin P.O. Box 240, Palestine., Jaber H; Laboratory of Natural Resources and Sustainable Development, Faculty of Science, University Ibn Tofail, Kenitra B.P 242, Morocco., Ettouil A; Laboratory of Natural Resources and Sustainable Development, Faculty of Science, University Ibn Tofail, Kenitra B.P 242, Morocco., Haida S; Laboratory of Separation Processes, Team of Environment and Applied Chemistry, Faculty of Sciences, Ibn Tofail University, Kenitra B.P 242, Morocco., Ouhssine M; Laboratory of Natural Resources and Sustainable Development, Faculty of Science, University Ibn Tofail, Kenitra B.P 242, Morocco., Noman OM; Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia., Mothana RA; Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia., Tarayrah M; Groupe Hospitalier Cochin-Port Royal, Faculty of Medicine, Institut Cochin, Paris University, CNRS, IN-SERM, 75000 Paris, France., Guessous Z; Laboratory of Natural Resources and Sustainable Development, Faculty of Science, University Ibn Tofail, Kenitra B.P 242, Morocco. |
| Abstrakt: |
The present study was conducted to evaluate the acute toxicity and anti-inflammatory effect in vivo, as well as the antioxidant activity, of the essential oil of Thymus leptobotrys Murb . The results indicate that the tested essential oil is non-toxic, with an estimated LD50 of 2500 mg kg -1 of mice body weight. The anti-inflammatory test revealed that, at a dose of 200 mg kg -1 , the essential oil reduced rat paw edemas by 89.59% within 3 h of oral administration, this reduction in edema size was greater than that obtained with indomethacin (75.78%). The antioxidant activity (IC50) of Thymus leptobotrys Murb essential oil was 346.896 µg mL -1 and 861.136 mg Trolox equivalent/g essential oil in the 2.2-diphenyl1-picryl-hydrazyl radical scavenging capacity (DPPH) and Trolox equivalent antioxidant capacity (TEAC) assays, respectively. The toxicity test reveals an LD 50 greater than 2500 mg kg -1 of body weight of mice which classifies it within category 5 of non-toxic substances that can be administered orally. These results suggest that the essential oil of Thymus leptobotrys Murb is not toxic, and it represents a valuable source of anti-inflammatory and antioxidant metabolites. |
