| Autor: |
Piqué B; Molecular Pathology Unit, Department of Pathology, Hospital Universitari Sant Joan de Reus, Institut d'Investigació Sanitàri Pere Virgili, Universitat Rovira i Virgili, 43204 Tarragona, Spain., Peña K; Molecular Pathology Unit, Department of Pathology, Hospital Universitari Sant Joan de Reus, Institut d'Investigació Sanitàri Pere Virgili, Universitat Rovira i Virgili, 43204 Tarragona, Spain., Riu F; Molecular Pathology Unit, Department of Pathology, Hospital Universitari Sant Joan de Reus, Institut d'Investigació Sanitàri Pere Virgili, Universitat Rovira i Virgili, 43204 Tarragona, Spain., Acosta JC; Department of Radiation Oncology, Hospital Universitari Sant Joan de Reus, Institut d'Investigació Sanitàri Pere Virgili, Universitat Rovira i Virgili, 43204 Tarragona, Spain., Torres-Royo L; Department of Radiation Oncology, Hospital Universitari Sant Joan de Reus, Institut d'Investigació Sanitàri Pere Virgili, Universitat Rovira i Virgili, 43204 Tarragona, Spain., Malave B; Department of Radiation Oncology, Hospital Universitari Sant Joan de Reus, Institut d'Investigació Sanitàri Pere Virgili, Universitat Rovira i Virgili, 43204 Tarragona, Spain., Araguas P; Department of Radiation Oncology, Hospital Universitari Sant Joan de Reus, Institut d'Investigació Sanitàri Pere Virgili, Universitat Rovira i Virgili, 43204 Tarragona, Spain., Benavides R; Department of Radiation Oncology, Hospital Universitari Sant Joan de Reus, Institut d'Investigació Sanitàri Pere Virgili, Universitat Rovira i Virgili, 43204 Tarragona, Spain., de Febrer G; Department of Geriatric and Palliative Care, Hospital Universitari Sant Joan de Reus, 43204 Tarragona, Spain., Camps J; Unitat de Recerca Biomèdica, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, 43003 Tarragona, Spain., Joven J; Unitat de Recerca Biomèdica, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, 43003 Tarragona, Spain., Arenas M; Department of Radiation Oncology, Hospital Universitari Sant Joan de Reus, Institut d'Investigació Sanitàri Pere Virgili, Universitat Rovira i Virgili, 43204 Tarragona, Spain., Parada D; Molecular Pathology Unit, Department of Pathology, Hospital Universitari Sant Joan de Reus, Institut d'Investigació Sanitàri Pere Virgili, Universitat Rovira i Virgili, 43204 Tarragona, Spain. |
| Abstrakt: |
Several studies have shown that the plasma RNA of SARS-CoV-2 seems to be associated with a worse prognosis of COVID-19. In the present study, we investigated plasma RNA in COVID-19 patients treated with low-dose radiotherapy to determine its prognostic value. Data were collected from the IPACOVID prospective clinical trial (NCT04380818). The study included 46 patients with COVID-19 pneumonia treated with a whole-lung dose of 0.5 Gy. Clinical follow-up, as well as laboratory variables, and SARS-CoV-2 serum viral load, were analyzed before LDRT, at 24 h, and one week after treatment. The mean age of the patients was 85 years, and none received any of the SARS-CoV-2 vaccine doses. The mortality ratio during the course of treatment was 33%. RT-qPCR showed amplification in 23 patients. Higher mortality rate was associated with detectable viremia. Additionally, C-reactive protein, lactate dehydrogenase, and aspartate aminotransferase were significant risk factors associated with COVID-19 mortality. Our present findings show that detectable SARS-CoV-2 plasma viremia 24 h before LDRT is significantly associated with increased mortality rates post-treatment, thus downsizing the treatment success. |
