| Autor: |
Walker WH; Department of Obstetrics and Gynecology, Magee Womens Research Institute, University of Pittsburgh, Pittsburgh, PA 15260, USA., Cooke PS; Department of Physiological Sciences, University of Florida, Gainesville, FL 32611, USA. |
| Jazyk: |
angličtina |
| Zdroj: |
International journal of molecular sciences [Int J Mol Sci] 2023 Feb 01; Vol. 24 (3). Date of Electronic Publication: 2023 Feb 01. |
| DOI: |
10.3390/ijms24032748 |
| Abstrakt: |
Steroid hormones are capable of diffusing through cell membranes to bind with intracellular receptors to regulate numerous physiological processes. Three classes of steroid hormones, namely androgens, estrogens and glucocorticoids, contribute to the development of the reproductive system and the maintenance of fertility. During the past 30 years, mouse models have been produced in which the expression of genes encoding steroid hormone receptors has been enhanced, partially compromised or eliminated. These mouse models have revealed many of the physiological processes regulated by androgens, estrogens and to a more limited extent glucocorticoids in the testis and male accessory organs. In this review, advances provided by mouse models that have facilitated a better understanding of the molecular regulation of testis and reproductive tract processes by steroid hormones are discussed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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