Immunotherapy for Hepatocellular Carcinoma in the Setting of Liver Transplantation: A Review.

Autor: Lominadze Z; Division of Gastroenterology & Hepatology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA., Hill K; Department of Medicine, University of Maryland Medical Center, Baltimore, MD 21201, USA., Shaik MR; Department of Medicine, University of Maryland Medical Center Midtown Campus, Baltimore, MD 21201, USA., Canakis JP; Department of Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA., Bourmaf M; Department of Medicine, University of Maryland Medical Center, Baltimore, MD 21201, USA., Adams-Mardi C; Department of Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA., Abutaleb A; Department of Surgery, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA., Mishra L; Cold Spring Harbor Laboratory, Feinstein Institutes for Medical Research, Division of Gastroenterology and Hepatology, Northwell Health, Manhasset, NY 11030, USA., Shetty K; Division of Gastroenterology & Hepatology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Jazyk: angličtina
Zdroj: International journal of molecular sciences [Int J Mol Sci] 2023 Jan 25; Vol. 24 (3). Date of Electronic Publication: 2023 Jan 25.
DOI: 10.3390/ijms24032358
Abstrakt: The emerging field of immuno-oncology has brought exciting developments in the treatment of hepatocellular carcinoma (HCC). It has also raised urgent questions about the role of immunotherapy in the setting of liver transplantation, both before and after transplant. A growing body of evidence points to the safety and efficacy of immunotherapeutic agents as potential adjuncts for successful down-staging of advanced HCCs to allow successful transplant in carefully selected patients. For patients with recurrent HCC post-transplant, immunotherapy has a limited, yet growing role. In this review, we describe optimal regimens in the setting of liver transplantation.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje