Prediction of Mortality in Patients on Peritoneal Dialysis Based on the Fibrinogen Mannosylation.

Autor: Baralić M; School of Medicine, University of Belgrade, 11000 Belgrade, Serbia.; Clinic of Nephrology, University Clinical Centre of Serbia, 11000 Belgrade, Serbia., Pažitná L; Institute of Chemistry, Slovak Academy of Sciences, 84538 Bratislava, Slovakia., Brković V; School of Medicine, University of Belgrade, 11000 Belgrade, Serbia.; Clinic of Nephrology, University Clinical Centre of Serbia, 11000 Belgrade, Serbia., Laušević M; School of Medicine, University of Belgrade, 11000 Belgrade, Serbia.; Clinic of Nephrology, University Clinical Centre of Serbia, 11000 Belgrade, Serbia., Gligorijević N; Institute for the Application of Nuclear Energy (INEP), University of Belgrade, 11080 Belgrade, Serbia., Katrlík J; Institute of Chemistry, Slovak Academy of Sciences, 84538 Bratislava, Slovakia., Nedić O; Institute for the Application of Nuclear Energy (INEP), University of Belgrade, 11080 Belgrade, Serbia., Robajac D; Institute for the Application of Nuclear Energy (INEP), University of Belgrade, 11080 Belgrade, Serbia.
Jazyk: angličtina
Zdroj: Cells [Cells] 2023 Jan 17; Vol. 12 (3). Date of Electronic Publication: 2023 Jan 17.
DOI: 10.3390/cells12030351
Abstrakt: As we already reported, fibrinogen fucosylation emerged as a prognostic marker of peritoneal membrane function in end-stage renal disease (ESRD) patients on peritoneal dialysis. After a follow-up period of 18 months, we estimated the ability of employed lectins, as well as other biochemical parameters, to serve as mortality predictors in these patients. Following a univariate Cox regression analysis, ferritin, urea clearance, residual diuresis, hyperglycemia, and an increase in the signal intensity obtained with Galanthus nivalis lectin (GNL) emerged as potential mortality predictors, but additional multivariate Cox regression analysis pointed only to glucose concentration and GNL as mortality predictors. Higher signal intensity obtained with GNL in patients that died suggested the importance of paucimannosidic/highly mannosidic N-glycan structures on fibrinogen as factors that are related to unwanted cardiovascular events and all-cause mortality and can possibly be seen as a prediction tool. Altered glycan structures composed of mannose residues are expected to affect the reactivity of mannosylated glycoproteins with mannose-binding lectin and possibly the entire cascade of events linked to this lectin. Since patients with ESRD are prone to cardiovascular complications and the formation of atherosclerotic plaques, one can hypothesize that fibrinogen with increasingly exposed mannose residues may contribute to the unwanted events.
Competing Interests: The authors declare no conflict of interest.
Databáze: MEDLINE
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