The Role of mpMRI in the Assessment of Prostate Cancer Recurrence Using the PI-RR System: Diagnostic Accuracy and Interobserver Agreement in Readers with Different Expertise.

Autor: Bergaglio C; Department of Health Sciences (DISSAL), University of Genova, 16126 Genova, Italy., Giasotto V; Department of Radiology, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy., Marcenaro M; Department of Radiation Oncology, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy., Barra S; Department of Radiation Oncology, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy., Turazzi M; Department of Health Sciences (DISSAL), University of Genova, 16126 Genova, Italy., Bauckneht M; Department of Health Sciences (DISSAL), University of Genova, 16126 Genova, Italy.; Nuclear Medicine Unit, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy., Casaleggio A; Department of Radiology, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy., Sciabà F; Department of Health Sciences (DISSAL), University of Genova, 16126 Genova, Italy., Terrone C; Department of Urology, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy.; Department of Surgical Integrated Sciences (DISC), Urology Section, University of Genova, 16126 Genova, Italy., Mantica G; Department of Urology, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy.; Department of Surgical Integrated Sciences (DISC), Urology Section, University of Genova, 16126 Genova, Italy., Borghesi M; Department of Urology, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy.; Department of Surgical Integrated Sciences (DISC), Urology Section, University of Genova, 16126 Genova, Italy., Signori A; Department of Health Sciences (DISSAL), University of Genova, 16126 Genova, Italy., Spina B; Pathology Unit, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy., Piol N; Anatomia Patologica Universitaria Unit, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy., Zanardi E; Academic Unit of Medical Oncology, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy., Fornarini G; Medical Oncology Unit 1, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy., Zawaideh JP; Department of Radiology, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy.
Jazyk: angličtina
Zdroj: Diagnostics (Basel, Switzerland) [Diagnostics (Basel)] 2023 Jan 20; Vol. 13 (3). Date of Electronic Publication: 2023 Jan 20.
DOI: 10.3390/diagnostics13030387
Abstrakt: Background: treated prostate cancer (PCa) patients develop biochemical recurrence (BCR) in 27-53% of cases; the role of MRI in this setting is still controversial. In 2021 a panel of experts proposed a "Prostate Imaging-Recurrence Reporting" (PI-RR) score, aiming to standardize the reporting. The aim of our study is to evaluate the reproducibility of the PI-RR scoring system among readers with different expertise.
Methods: in this monocentric, retrospective observational study, the images of patients who underwent MRI with BCR from January 2017 to January 2022 were analyzed by two radiologists and a radiology resident. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy were obtained. Interobserver agreement was calculated. The percentage of the PI-RR score of 3 was estimated to find out the proportion of uncertain exams reported among the readers.
Results: a total of seventy-six patients were included in our study: eight previously treated with RT and sixty-eight who underwent surgery. The accuracy range was 75-80%, the sensitivity 68.4-71.1%, the specificity 81.6-89.5%, PPV 78.8-87.1%, and NPV 72.1-75.6%. The inter-reader agreement using a binary evaluation (PI-RR ≥ 3 as positive mpMRI) demonstrated a correlation coefficient (k) of 0.74 (95% CI: 0.62-0.87). The percentage for the PI-RR score of 3 was 6.6% for reader one, 14.5% for reader two, and 2.6% for reader three.
Conclusion: this study confirmed the good accuracy of mpMRI in the detection of local recurrence of PCa and the good reproducibility of PI-RR score among all readers, confirming it to be a promising tool for the standardization of the assessment of patients with BCR.
Databáze: MEDLINE
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