| Autor: |
Leite AK; Head and Neck Surgery Department, Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo 05403-010, SP, Brazil.; Faculdade Israelita de Ciências da Saúde Albert Einstein, Hospital Albert Einstein, São Paulo 05653-120, SP, Brazil., Saito KC; Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, SP, Brazil., Theodoro TR; Discipline of Biochemistry, Department of Morfology and Physiology, Faculdade de Medicina Do ABC, São Paulo 09060-870, SP, Brazil., Pasini FS; Centro de Investigação Translacional em Oncologia, Instituto do Câncer do Estado de São Paulo Paulo (ICESP), Hospital das Clínicas (HCFMUSP), Faculdade de Medicina da Universidade de São Paulo, Sao Paulo 01246-000, SP, Brazil., Camilo LP; Faculdade Israelita de Ciências da Saúde Albert Einstein, Hospital Albert Einstein, São Paulo 05653-120, SP, Brazil., Rossetti CA; Faculdade Israelita de Ciências da Saúde Albert Einstein, Hospital Albert Einstein, São Paulo 05653-120, SP, Brazil., Cavalheiro BG; Head and Neck Surgery Department, Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo 05403-010, SP, Brazil., Alves VAF; Pathology Department, Instituto do Câncer do Estado de São Paulo, Laboratório de Investigação Médica 14 (LIM14), Faculdade de Medicina da Universidade de São Paulo, São Paulo 01246-903, SP, Brazil., Kowalski LP; Head and Neck Surgery Department, Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo 05403-010, SP, Brazil., Pinhal MAS; Discipline of Biochemistry, Department of Morfology and Physiology, Faculdade de Medicina Do ABC, São Paulo 09060-870, SP, Brazil., Kimura ET; Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, SP, Brazil., Matos LL; Head and Neck Surgery Department, Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo 05403-010, SP, Brazil.; Faculdade Israelita de Ciências da Saúde Albert Einstein, Hospital Albert Einstein, São Paulo 05653-120, SP, Brazil. |
| Abstrakt: |
Papillary thyroid carcinoma (PTC) is the most common neoplasm of the endocrine system and has an excellent long-term prognosis, with low rates of distant metastatic disease. Although infrequent, there are cases of deaths directly related to PTC, especially in patients with metastatic disease, and the factors that could be associated with this unfavorable outcome remain a major challenge in clinical practice. Recently, research into genetic factors associated with PTC has gained ground, especially mutations in the TERT promoter and BRAF gene. However, the role of microRNAs remains poorly studied, especially in those patients who have an unfavorable outcome at follow-up. This paper aims to evaluate molecular markers related to the different pathological processes of PTC, as well as the histological characteristics of the neoplasm, and to compare this profile with prognosis and death from the disease using an analysis of patients treated for metastatic disease in a single tertiary cancer center. Evaluation of microRNA expression in paraffin-embedded tumor specimens was carried out by quantitative PCR using the TaqMan ® Low Density Array (TLDA) system. Metastatic patients who died from progression of PTC had higher expressions of miR-101-3p, miR-17-5p, and miR-191-5p when compared to patients with stable metastatic disease. These findings are of great importance but should be considered as preliminary because of the small sample. |
