Feasibility of joint mapping of triglyceride saturation and water longitudinal relaxation in a single breath hold applied to high fat-fraction adipose depots in the periclavicular anatomy.

Autor: Ostenson J; Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States of America; Dept. of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States of America. Electronic address: j.ostenson@vumc.org., Robison RK; Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States of America; Philips, Gainesville, FL, United States of America., Brittain EL; Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN, United States of America., Damon BM; Dept. of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States of America; Carle Clinical Imaging Research Program, Urbana, IL, United States of America; Stephens Family Clinical Research Institute, Carle Health, Urbana, IL, United States of America; Department of Bioengineering and Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, IL, United States of America; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States of America.
Jazyk: angličtina
Zdroj: Magnetic resonance imaging [Magn Reson Imaging] 2023 Jun; Vol. 99, pp. 58-66. Date of Electronic Publication: 2023 Feb 09.
DOI: 10.1016/j.mri.2023.02.001
Abstrakt: Introduction: Simultaneous mapping of triglyceride (TAG) saturation and tissue water relaxation may improve the characterization of the structure and function of anatomies with significant adipose tissue. While several groups have demonstrated in vivo TAG saturation imaging using MRI, joint mapping of relaxation and TAG saturation is understudied. Such mappings may avoid bias from physiological motion, if they can be done within a single breath-hold, and also account for static and applied magnetic field heterogeneity.
Methods: We propose a transient-state/MR fingerprinting single breath-hold sequence at 3 T, a low-rank reconstruction, and a parameter estimation pipeline that jointly estimates the number of double bonds (NDB), number of methylene interrupted double bonds (NMIDB), and tissue water T 1 , while accounting for non-ideal radiofrequency transmit scaling and off-resonance effects. We test the proposed method in simulations, in phantom against MR spectroscopy (MRS), and in vivo regions in and around high fat fraction (FF) periclavicular adipose tissue. Partial volume and multi-peak transverse relaxation effects are explored.
Results: The simulation results demonstrate accurate NDB, NMIDB, and water T 1 estimates across a range of NDB, NMIDB, and T 1 values. In phantoms, the proposed method's estimates of NDB and NMIDB correlate with those from MR spectroscopy (Pearson correlation ≥0.98), while the water T 1 estimates are concordant with a standard phantom. The NDB and NMIDB are sensitive to partial volumes of water, showing increasing bias at FF < 40%. This bias is found to be due to noise and transverse relaxation effects. The in vivo periclavicular adipose tissue has high FF (>90%). The adipose tissue NDB and NMIDB, and muscle T 1 estimates are comparable to those reported in the literature.
Conclusion: Robust estimation of NDB, NMIDB at high FF and water T 1 across a broad range of FFs are feasible using the proposed methods. Further reduction of noise and model bias are needed to employ the proposed technique in low FF anatomies and pathologies.
Competing Interests: Declaration of Competing Interest None.
(Copyright © 2023. Published by Elsevier Inc.)
Databáze: MEDLINE
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