Investigating the effect of pregabalin on postoperative pain in non-emergency craniotomy.

Autor: Sane S; Department of Anesthesiology, Urmia Imam Khomeini Hospital, Urmia University of Medical Sciences, Urmia, Iran., Mahoori A; Department of Anesthesiology, Urmia Imam Khomeini Hospital, Urmia University of Medical Sciences, Urmia, Iran., Abdulabbas HS; Continuous Education Department, Faculty of Dentistry, University of Al-Ameed, Karbala 56001, Iraq., Alshahrani SH; Medical-Surgical Nursing Department, King Khalid University, Khamis Mushate, Saudi Arabia., Qasim MT; Department of Anesthesia, College of Health and Medical Technololgy, Al-Ayen University, Thi-Qar, Iraq., Abosaooda M; College of Pharmacy, the Islamic University, 54001 Najaf, Iraq., Nozad P; Department of Anesthesiology, Urmia Imam Khomeini Hospital, Urmia University of Medical Sciences, Urmia, Iran., Khanahmadi S; Department of Anesthesiology, Urmia Imam Khomeini Hospital, Urmia University of Medical Sciences, Urmia, Iran., Golabi P; Department of Anesthesiology, Omid Charity Hospital, Urmia University of Medical Sciences, Urmia, Iran., Kazemi Haki B; Department of Anesthesiology, Urmia Imam Khomeini Hospital, Urmia University of Medical Sciences, Urmia, Iran., Darvishzadehdaledari S; Department of Health Sciences, University of York, Heslington, York, United Kingdom. Electronic address: sd1799@york.ac.uk.
Jazyk: angličtina
Zdroj: Clinical neurology and neurosurgery [Clin Neurol Neurosurg] 2023 Mar; Vol. 226, pp. 107599. Date of Electronic Publication: 2023 Jan 20.
DOI: 10.1016/j.clineuro.2023.107599
Abstrakt: Background: Surgical procedures performed in the suboccipital and subtemporal regions are associated with severe pain. The present study was designed to determine pregabalin's effect on postoperative pain in elective craniotomy.
Method: This double-blind prospective randomized clinical trial was conducted on 50 patients aged 20-60 with ASA classifications I and II. The patients who qualified for elective craniotomies were split into intervention (two capsules =300 mg pregabalin) and control groups (two capsule starch). Patients were also assessed at recovery, 2, 6, 12, and 24 h after surgery for their pain and level of sedation. Data were analyzed by SPSS software version 23, and a P-value ≤ 0.05 was considered significant.
Results: The mean pain score in the intervention group was lower than the control group at recovery (p = 0.224), 2 h (p = 0.001), 6 h (p = 0.011), and 12 h (p = 0.032) after surgery. The methadone consumption in the control group was significantly higher than the intervention group (p < 0.05). There was no significant difference between the two groups regarding the level of sedation (p > 0.05). The mean heart rate at induction (p = 0.01), 15 min (p = 0.01), 30 min (p = 0.025), recovery (p = 0.031), and 2 h (p = 0.021) after surgery and the MAP at recovery, 2 h, and 6 h after surgery was significantly lower than the control group (p = 0.029), (p = 0.013), and (p = 0.038), respectively.
Conclusion: Our investigation demonstrated the effectiveness of pregabalin two hours before surgery on decreasing postoperative pain and analgesic consumption without disturbance in neurological examinations and any specific adverse effects.
Competing Interests: Conflict of Interests The authors declare that there were no competing interests.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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