Efficacy and safety profile of GreenLight laser photoselective vaporization of the prostate in ≥ 75 years old patients: results from the Italian GreenLight Laser Study Group.

Autor: Campobasso D; Urology Unit, Civil Hospital of Guastalla, Azienda USL-IRCCS di Reggio Emilia, Via Donatori di Sangue 1, 42016, Guastalla, RE, Italy. d.campobasso@virgilio.it.; Department of Urology, University Hospital of Parma, Parma, Italy. d.campobasso@virgilio.it., Morselli S; Department of Urology, 'Hesperia Hospital', Centro Urologico Europeo (C.Ur.E), Modena, Italy.; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy., Greco F; Urologic Clinic, Centro Salute Uomo, Bergamo, Italy., De Nunzio C; Department of Urology, 'Sant'Andrea' Hospital, Sapienza University, Rome, Italy., Destefanis P; Department of Urology, Azienda Ospedaliera Città della Salute e della Scienza di Turin-Sede Molinette, Turin, Italy., Fasolis G; Department of Urology, 'S. Lazzaro' Hospital, Alba, Italy., Varvello F; Department of Urology, 'S. Lazzaro' Hospital, Alba, Italy., Voce S; Department of Urology, Santa Maria delle Croci Hospital', Ravenna, Italy., Reale G; Department of Urology, Santa Maria delle Croci Hospital', Ravenna, Italy., Cai T; Department of Urology, Santa Chiara Regional Hospital, Trento, Italy., Oriti R; Department of Urology, 'Ulivella e Glicini Clinic', Florence, Italy., Tuccio A; Department of Urology, University of Florence, Unit of Oncologic Minimally-Invasive Urology and Andrology, Careggi Hospital, Florence, Italy., Ruggera L; Department of Urology, Clinica Urologica Azienda Ospedaliera - University of Padova, Padua, Italy., Laganà A; Department of Urology, 'S. Giovanni Evangelista' Hospital, Tivoli, Italy., Dadone C; Department of Urology, Santa Croce e Carle' Hospital, Cuneo, Italy., Gontero P; Department of Urology, Azienda Ospedaliera Città della Salute e della Scienza di Turin-Sede Molinette, Turin, Italy., De Rienzo G; Department of Emergency and Organ Transplantation, Urology and Andrology Unit II, University of Bari, Bari, Italy., Pucci L; Department of Urology, AORN 'Antonio Cardarelli', Naples, Italy., Carrino M; Department of Urology, AORN 'Antonio Cardarelli', Naples, Italy., Montefiore F; Department of Urology, San Giacomo' Hospital, Novi Ligure, Italy., Rabito S; Department of Urology, 'Hesperia Hospital', Centro Urologico Europeo (C.Ur.E), Modena, Italy., Miano R; UOSD Urologia, Fondazione Policlinico Tor Vergata, Rome, Italy., Schips L; Department of Medical, Oral and Biotechnological Sciences, 'G. D'Annunzio' University of Chieti, Chieti, Italy., Frattini A; Urology Unit, Civil Hospital of Guastalla, Azienda USL-IRCCS di Reggio Emilia, Via Donatori di Sangue 1, 42016, Guastalla, RE, Italy., Micali S; Department of Urology, University of Modena and Reggio Emilia, Modena, Italy., Ferrari G; Department of Urology, 'Hesperia Hospital', Centro Urologico Europeo (C.Ur.E), Modena, Italy., Cindolo L; Department of Urology, 'Hesperia Hospital', Centro Urologico Europeo (C.Ur.E), Modena, Italy.; Department of Urology, 'Villa Stuart' Private Hospital, Rome, Italy.
Jazyk: angličtina
Zdroj: Aging clinical and experimental research [Aging Clin Exp Res] 2023 Apr; Vol. 35 (4), pp. 877-885. Date of Electronic Publication: 2023 Feb 10.
DOI: 10.1007/s40520-023-02351-9
Abstrakt: Background: Benign Prostatic Obstruction (BPO) is the most common non-malignant urological condition among men and its incidence rise with age. Among prostate treatments, GreenLight laser seems to reduce bleeding and would be safer in the aging population.
Aims: We aimed to compare the functional outcomes and safety profile of < 75 years old (Group A) and ≥ 75 years old (Group B) patients.
Methods: In a multicenter setting, we retrospectively analyzed all the patients treated with GreenLight Laser vaporization of the prostate (PVP).
Results: 1077 patients were eligible for this study. 757 belonged to Group A (median age 66 years) and 320 to Group B (median age 78 years). No differences were present between the two groups in terms of prostate volume, operative time, hospital stay, PSA decrease over time after surgery, complications and re-intervention rate with a median follow-up period of 18 months (IQR 12-26). Nevertheless, focusing on complications, GreenLight laser PVP demonstrated an excellent safety profile in terms of hospital stay, re-intervention and complications, with an overall 29.6% complication rate in older patients and only two cases of Clavien III. Functional outcomes were similar at 12 month and became in favor of Group A over time. These data are satisfactory with a Qmax improvement of 111.7% and an IPSS reduction of 69.5% in older patients.
Discussion and Conclusions: GreenLight laser photoselective vaporization of the prostate is a safe and efficient procedure for all patients, despite their age, with comparable outcomes and an equal safety profile.
(© 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)
Databáze: MEDLINE
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