Development and validation of risk calculators for people with "thin" melanomas on their skin to predict the likelihood that their cancer will return: a plain language summary of publication.

Autor:	Sharouni ME; Department of Dermatology, University Medic al Center Utrecht, Utrecht University, Utrecht, the Netherlands.; Melanoma Institute Australia, The University of Sydney, North Sydney, NSW, Australia., Lo SN; Melanoma Institute Australia, The University of Sydney, North Sydney, NSW, Australia.; Faculty of Medicine & Health, The University of Sydney, Sydney, NSW, Australia., Varey AH; Department of Dermatology, University Medic al Center Utrecht, Utrecht University, Utrecht, the Netherlands.; Faculty of Medicine & Health, The University of Sydney, Sydney, NSW, Australia.; Department of Plastic & Reconstructive Surgery, Westmead Hospital, Sydney, NSW, Australia., Elias SG; Julius Center for Health Sciences & Primary Care, University Medical Center Utrecht, University Utrecht, Utrecht, the Netherlands., Witkamp AJ; Department of Surgery, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Sigurdsson V; Department of Dermatology, University Medic al Center Utrecht, Utrecht University, Utrecht, the Netherlands., Suijkerbuijk KP; Department of Medical Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., van Diest PJ; Department of Pathology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., van Gils CH; Julius Center for Health Sciences & Primary Care, University Medical Center Utrecht, University Utrecht, Utrecht, the Netherlands., Blokx WA; Department of Pathology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Scolyer RA; Melanoma Institute Australia, The University of Sydney, North Sydney, NSW, Australia.; Faculty of Medicine & Health, The University of Sydney, Sydney, NSW, Australia.; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia., Thompson JF; Melanoma Institute Australia, The University of Sydney, North Sydney, NSW, Australia.; Faculty of Medicine & Health, The University of Sydney, Sydney, NSW, Australia.; Department of Melanoma & Surgical Oncology, Royal Prince Alfred Hospital, Sydney, NSW, Australia.
Jazyk:	angličtina
Zdroj:	Future oncology (London, England) [Future Oncol] 2023 Jan; Vol. 19 (2), pp. 97-102. Date of Electronic Publication: 2023 Feb 10.
DOI:	10.2217/fon-2022-0525
Abstrakt:	What Is This Summary About?: This is a summary of an article describing the development of risk calculators for use in people who develop a type of melanoma on their skin called "thin" melanoma to predict the likelihood that their cancer will return. The article was originally published in the Journal of Clinical Oncology in 2021. How Were the Calculators Developed?: Calculations were performed to predict the chance of people with thin melanomas surviving without their melanoma recurring. Three graphical prediction calculators (called nomograms) were developed, along with easy-to-use online calculators using the same underlying calculation methods. The model was developed using data for 25,930 Dutch people diagnosed with thin melanomas (called the "development set"). To test its ability to predict melanoma recurrence, it was then compared with data for 2,968 Australian people with melanoma (the "validation set"). The calculators developed in the Dutch patients were found to accurately predict the risk of melanoma recurring for people with melanoma in the Australian "validation" group. What Do the Results Mean?: The calculators provide estimates of the risk of the melanoma returning for people with thin melanomas. The easy-to-use online calculators are freely available on a smartphone, tablet or computer, and will assist in providing accurate estimates of recurrence risks for individuals with thin melanomas, allowing more intensive follow-up of those whose predicted risk of their melanoma returning is high.
Databáze:	MEDLINE
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