Overcoming barriers: Modelling the effect of potential future changes of organized breast cancer screening in Italy.

Autor:	Zielonke N; Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Senore C; Epidemiology and screening Unit - CPO, University Hospital Città della Salute e della Scienza, Turin, Italy., Ponti A; Epidemiology and screening Unit - CPO, University Hospital Città della Salute e della Scienza, Turin, Italy., Csanadi M; Syreon Research Institute, Budapest, Hungary., de Koning HJ; Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Heijnsdijk EAM; Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., van Ravesteyn NT; Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Jazyk:	angličtina
Zdroj:	Journal of medical screening [J Med Screen] 2023 Sep; Vol. 30 (3), pp. 134-141. Date of Electronic Publication: 2023 Feb 10.
DOI:	10.1177/09691413231153568
Abstrakt:	Objectives: Organized breast cancer screening may not achieve its full potential due to organizational and cultural barriers. In Italy, two identified barriers were low attendance in Southern Italy and, in Italy as a whole, underscreening and overscreening in parts of the eligible population. The objective of this study was to identify potential changes to overcome these barriers and to quantify their costs and effects. Methods: To assess the impact of potential measures to improve breast cancer screening in Italy, we performed an evaluation of costs and effects for increasing adherence for Southern Italy and harmonizing screening intervals (biennial screening) for the whole of Italy, using an online tool (EU-TOPIA evaluation tool) based on the MIcrosimulation SCreening ANalysis (MISCAN) model. Results: Increasing adherence in Southern Italy through investing in mobile screening units has an acceptable cost-effectiveness ratio of €9531 per quality-adjusted life year gained. Harmonizing the screening interval by investing in measures to reduce opportunistic screening and simultaneously investing in mobile screening units to reduce underscreening is predicted to gain 1% fewer life-years, while saving 19% of total screening costs compared to the current situation. Conclusions: Increasing adherence in Southern Italy and harmonizing the screening interval could result in substantial improvements at acceptable costs, or in the same benefits at lower costs. This example illustrates a systematic approach that can be easily applied to other European countries, as the online tools can be used by stakeholders to quantify effects and costs of a broad range of specific barriers, and ways to overcome them.
Databáze:	MEDLINE
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