CellPalmSeq: A curated RNAseq database of palmitoylating and de-palmitoylating enzyme expression in human cell types and laboratory cell lines.

Autor:	Wild AR; Bamji Lab, Department of Cellular and Physiological Sciences, Life Sciences Institute and Djavad Mowafaghian Centre for Brain Health, Vancouver, BC, Canada., Hogg PW; Bamji Lab, Department of Cellular and Physiological Sciences, Life Sciences Institute and Djavad Mowafaghian Centre for Brain Health, Vancouver, BC, Canada., Flibotte S; Life Sciences Institute Bioinformatics Facility, University of British Columbia, Vancouver, BC, Canada., Kochhar S; Bamji Lab, Department of Cellular and Physiological Sciences, Life Sciences Institute and Djavad Mowafaghian Centre for Brain Health, Vancouver, BC, Canada., Hollman RB; Bamji Lab, Department of Cellular and Physiological Sciences, Life Sciences Institute and Djavad Mowafaghian Centre for Brain Health, Vancouver, BC, Canada., Haas K; Bamji Lab, Department of Cellular and Physiological Sciences, Life Sciences Institute and Djavad Mowafaghian Centre for Brain Health, Vancouver, BC, Canada., Bamji SX; Bamji Lab, Department of Cellular and Physiological Sciences, Life Sciences Institute and Djavad Mowafaghian Centre for Brain Health, Vancouver, BC, Canada.
Jazyk:	angličtina
Zdroj:	Frontiers in physiology [Front Physiol] 2023 Jan 24; Vol. 14, pp. 1110550. Date of Electronic Publication: 2023 Jan 24 (Print Publication: 2023).
DOI:	10.3389/fphys.2023.1110550
Abstrakt:	The reversible lipid modification protein S-palmitoylation can dynamically modify the localization, diffusion, function, conformation and physical interactions of substrate proteins. Dysregulated S-palmitoylation is associated with a multitude of human diseases including brain and metabolic disorders, viral infection and cancer. However, the diverse expression patterns of the genes that regulate palmitoylation in the broad range of human cell types are currently unexplored, and their expression in commonly used cell lines that are the workhorse of basic and preclinical research are often overlooked when studying palmitoylation dependent processes. We therefore created CellPalmSeq (https://cellpalmseq.med.ubc.ca), a curated RNAseq database and interactive webtool for visualization of the expression patterns of the genes that regulate palmitoylation across human single cell types, bulk tissue, cancer cell lines and commonly used laboratory non-human cell lines. This resource will allow exploration of these expression patterns, revealing important insights into cellular physiology and disease, and will aid with cell line selection and the interpretation of results when studying important cellular processes that depend on protein S-palmitoylation. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Wild, Hogg, Flibotte, Kochhar, Hollman, Haas and Bamji.)
Databáze:	MEDLINE
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