Colonic Dilatation Complicating Acute Severe Ulcerative Colitis Managed Successfully with Accelerated Infliximab Dosing.

Autor: Bui HH; Department of Gastroenterology, University Medical Center Ho Chi Minh City, Ho Chi Minh City, Vietnam.; Department of Internal Medicine, University Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam., Dang LM; Department of Gastroenterology, University Medical Center Ho Chi Minh City, Ho Chi Minh City, Vietnam.; Department of Internal Medicine, University Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam., Thi-Ngoc Vo D; Department of Pathology, University Medical Center Ho Chi Minh City, Ho Chi Minh City, Vietnam.; Department of Pathology, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam., Nguyen CD; Department of Gastroenterology, University Medical Center Ho Chi Minh City, Ho Chi Minh City, Vietnam.
Jazyk: angličtina
Zdroj: Case reports in gastroenterology [Case Rep Gastroenterol] 2023 Feb 07; Vol. 17 (1), pp. 82-88. Date of Electronic Publication: 2023 Feb 07 (Print Publication: 2023).
DOI: 10.1159/000529152
Abstrakt: Lately, emerging data suggest an association between the development of inflammatory bowel disease and anti-interleukin-17 therapy. Megacolon is a life-threatening complication of acute severe ulcerative colitis (ASUC), but its treatment has not yet been established in current practice guidelines. We report a rare case of known psoriasis treated by secukinumab in a patient who presented with ASUC and colonic dilatation. Neither steroids nor standard infliximab regimen was effective. Finally, rescue therapy with accelerated infliximab strategy resulted in excellent recovery. In certain cases of steroid-refractory ASUC complicated by megacolon, accelerated infliximab regimen can be an alternative to surgery.
Competing Interests: The authors have no conflicts of interest to declare.
(© 2023 The Author(s). Published by S. Karger AG, Basel.)
Databáze: MEDLINE
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