Static first-minute-frame (FMF) PET imaging after 18 F-labeled amyloid tracer injection is correlated to [ 18 F]FDG PET in patients with primary progressive aphasia.

Autor: Gómez-Grande A; Department of Nuclear Medicine, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain; Facultad de Medicina, Universidad Complutense de Madrid, 28040 Madrid, Spain. Electronic address: adolfo.gomez@salud.madrid.org., Seiffert AP; Biomedical Engineering and Telemedicine Centre, ETSI Telecomunicación, Center for Biomedical Technology, Universidad Politécnica de Madrid, Madrid, Spain. Electronic address: ap.seiffert@upm.es., Villarejo-Galende A; Facultad de Medicina, Universidad Complutense de Madrid, 28040 Madrid, Spain; Department of Neurology, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain; Group of Neurodegenerative Diseases, Hospital 12 de Octubre Research Institute (imas12), 28041 Madrid, Spain; Biomedical Research Networking Center in Neurodegenerative Diseases (CIBERNED), 28029 Madrid, Spain., González-Sánchez M; Department of Neurology, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain; Group of Neurodegenerative Diseases, Hospital 12 de Octubre Research Institute (imas12), 28041 Madrid, Spain; Biomedical Research Networking Center in Neurodegenerative Diseases (CIBERNED), 28029 Madrid, Spain., Llamas-Velasco S; Department of Neurology, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain; Group of Neurodegenerative Diseases, Hospital 12 de Octubre Research Institute (imas12), 28041 Madrid, Spain; Biomedical Research Networking Center in Neurodegenerative Diseases (CIBERNED), 28029 Madrid, Spain., Bueno H; Facultad de Medicina, Universidad Complutense de Madrid, 28040 Madrid, Spain; Department of Cardiology and Instituto de Investigación Sanitaria (imas12), 28041 Hospital Universitario 12 de Octubre, Madrid, Spain; Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain; Centro de Investigación Biomédica en Red de enfermedades Cardiovasculares (CIBERCV), 28029 Madrid, Spain., Gómez EJ; Biomedical Engineering and Telemedicine Centre, ETSI Telecomunicación, Center for Biomedical Technology, Universidad Politécnica de Madrid, Madrid, Spain; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina, Instituto de Salud Carlos III, 28029 Madrid, Spain., Tabuenca MJ; Department of Nuclear Medicine, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain., Sánchez-González P; Biomedical Engineering and Telemedicine Centre, ETSI Telecomunicación, Center for Biomedical Technology, Universidad Politécnica de Madrid, Madrid, Spain; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina, Instituto de Salud Carlos III, 28029 Madrid, Spain.
Jazyk: angličtina
Zdroj: Revista espanola de medicina nuclear e imagen molecular [Rev Esp Med Nucl Imagen Mol (Engl Ed)] 2023 Jul-Aug; Vol. 42 (4), pp. 211-217. Date of Electronic Publication: 2023 Feb 07.
DOI: 10.1016/j.remnie.2023.02.001
Abstrakt: Objective: To study the correlation between a static PET image of the first-minute-frame (FMF) acquired with 18 F-labeled amyloid-binding radiotracers and brain [ 18 F]FDG PET in patients with primary progressive aphasia (PPA).
Material and Methods: The study cohort includes 17 patients diagnosed with PPA with the following distribution: 9 nonfluent variant PPA, 4 logopenic variant PPA, 1 semantic variant PPA, 3 unclassifiable PPA. Regional SUVRs are extracted from FMFs and their corresponding [ 18 F]FDG PET images and Pearson's correlation coefficients are calculated.
Results: SUVRs of both images show similar patterns of regional cerebral alterations. Intrapatient correlation analyses result in a mean coefficient of r=0.94±0.06. Regional interpatient correlation coefficients of the study cohort are greater than 0.81. Radiotracer-specific and variant-specific subcohorts show no difference in the similarity between the images.
Conclusions: The static FMF could be a valid alternative to dynamic early-phase amyloid PET proposed in the literature, and a neurodegeneration biomarker for the diagnosis and classification of PPA in amyloid PET studies.
(Copyright © 2023 The Author(s). Published by Elsevier España, S.L.U. All rights reserved.)
Databáze: MEDLINE
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