| Autor: |
Gochicoa-Rangel L; Departamento de Fisiología Respiratoria, Instituto Nacional de Enfermedades Respiratorias 'Ismael Cosío Villegas,' Ciudad de México, México., Arce SC; Pulmonary Function Laboratory, Instituto de Investigaciones Médicas A. Lanari, Universidad de Buenos Aires, Buenos Aires, Argentina., Aguirre-Franco C; Servicio de Pruebas de Función Pulmonar, Fundación Neumológica Colombiana, Bogotá, Colombia., Madrid-Mejía W; Departamento de Fisiología Respiratoria, Instituto Nacional de Enfermedades Respiratorias 'Ismael Cosío Villegas,' Ciudad de México, México., Gutiérrez-Clavería M; Hospital Naval Viña del Mar Chile, Viña del Mar, Chile., Noriega-Aguirre L; Centro de Diagnóstico y Tratamiento de Enfermedades Respiratorias CEDITER, Cd. De Panamá, Panamá., Schonffeldt-Guerrero P; Instituto Nacional del Torax, Santiago de Chile, Chile., Acuña-Izcaray A; Servicio de Neumonología, Centro Médico Docente La Trinidad y Hospital Universitario de Caracas, Universidad Central de Venezuela, Caracas, Venezuela., Cortés-Telles A; Clínica de Enfermedades Respiratorias, HRAE de la Península de Yucatán, Mérida, México., Martínez-Valdeavellano L; Instituto Guatemalteco de Seguridad Social, Ciudad de Guatemala, Guatemala., Hernández-Rocha FI; BreathBaja, Mexicali, México., Ceballos-Zúñiga O; BreathBaja, Mexicali, México.; Hospital General de Mexicali, Mexicali, México., Del Rio Hidalgo R; Hospital Regional Dr. Valentín Gómez Farías ISSSTE, Guadalajara, México., Sánchez S; Centro de Estudios Respiratorios, Asunción, Paraguay., Meneses-Tamayo E; Departamento de Fisiología Respiratoria, Instituto Nacional de Enfermedades Respiratorias 'Ismael Cosío Villegas,' Ciudad de México, México., Chérrez-Ojeda I; Universidad de Especialidades Espíritu Santo, Samborondón, Ecuador.; Respiralab Research Center, Guayaquil, Ecuador. |
| Abstrakt: |
Laura Gochicoa-Rangel, Santiago C. Arce, Carlos Aguirre-Franco, Wilmer Madrid-Mejía, Mónica Gutiérrez-Clavería, Lorena Noriega-Aguirre, Patricia Schonffeldt-Guerrero, Agustín Acuña-Izcaray, Arturo Cortés-Telles, Luisa Martínez-Valdeavellano, Federico Isaac Hernández-Rocha, Omar Ceballos-Zúñiga, Rodrigo Del Rio Hidalgo, Sonia Sánchez, Erika Meneses-Tamayo, and Iván Chérrez-Ojeda; and on Behalf of the Respiratory Physiology Project in COVID-19 (FIRCOV). Effect of altitude on respiratory functional status in COVID-19 survivors: results from a Latin American Cohort-FIRCOV. High Alt Med Biol 24:37-48, 2023. Persistent symptoms and lung function abnormalities are common in COVID-19 survivors. Objectives: To determine the effect of altitude and other independent variables on respiratory function in COVID-19 survivors. Methods: Analytical, observational, cross-sectional cohort study done at 13 medical centers in Latin America located at different altitudes above sea level. COVID-19 survivors were invited to perform pulmonary function tests at least 3 weeks after diagnosis. Results: 1,368 participants (59% male) had mild (20%), moderate (59%), and severe (21%) disease. Restriction by spirometry was noted in 32%; diffusing capacity of the lung for carbon monoxide (DLCO) was low in 43.7%; and 22.2% walked less meters during the 6-minute walk test (6-MWT). In multiple linear regression models, higher altitude was associated with better spirometry, DLCO and 6-MWT, but lower oxygen saturation at rest and during exercise. Men were 3 times more likely to have restriction and 5.7 times more likely to have a low DLCO. Those who had required mechanical ventilation had lower DLCO and walked less during the 6-MWT. Conclusions: Men were more likely to have lower lung function than women, even after correcting for disease severity and other factors. Patients living at a higher altitude were more likely to have better spirometric patterns and walked farther but had lower DLCO and oxygen saturation. |
