Modeling brain and neural crest neoplasms with human pluripotent stem cells.

Autor:	Schloo C; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; Division of Neuroblastoma Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany., Kutscher LM; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; Developmental Origins of Pediatric Cancer Junior Research Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Jazyk:	angličtina
Zdroj:	Neuro-oncology [Neuro Oncol] 2023 Jul 06; Vol. 25 (7), pp. 1225-1235.
DOI:	10.1093/neuonc/noad034
Abstrakt:	Pluripotent stem cells offer unique avenues to study human-specific aspects of disease and are a highly versatile tool in cancer research. Oncogenic processes and developmental programs often share overlapping transcriptomic and epigenetic signatures, which can be reactivated in induced pluripotent stem cells. With the emergence of brain organoids, the ability to recapitulate brain development and structure has vastly improved, making in vitro models more realistic and hence more suitable for biomedical modeling. This review highlights recent research and current challenges in human pluripotent stem cell modeling of brain and neural crest neoplasms, and concludes with a call for more rigorous quality control and for the development of models for rare tumor subtypes. (© The Author(s) 2023. Published by Oxford University Press on behalf of the Society for Neuro-Oncology.)
Databáze:	MEDLINE
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