| Autor: |
Lee HX; Department of Chemistry and Biochemistry, Faculty of Science and Engineering, University of Northern British Columbia, Prince George, British Columbia, Canada., Yaqoob A; Department of Chemistry and Biochemistry, Faculty of Science and Engineering, University of Northern British Columbia, Prince George, British Columbia, Canada., Li WM; Department of Chemistry and Biochemistry, Faculty of Science and Engineering, University of Northern British Columbia, Prince George, British Columbia, Canada., Lee CH; Department of Chemistry and Biochemistry, Faculty of Science and Engineering, University of Northern British Columbia, Prince George, British Columbia, Canada. |
| Abstrakt: |
The ethanol extract of the fungus Sarcodon scabripes collected from north-central British Columbia, Canada, showed strong antiproliferative activity. Bioassay-guided purification using liquid-liquid extraction and Sephadex LH-20 size-exclusion chromatography, followed by HPLC-MS and 1D/2D NMR analyses, led to the isolation of five known compounds; four p -terphenyl ( 1 - 4 ) derivatives and one phenolic aldehyde ( 5 ). Compounds 1 , 4 , and 5 were isolated for the first time from the Sarcodon genus. The cytotoxicity MTT assay showed that compounds 1 - 5 have antiproliferative activity against human cervical cancer cells (HeLa). For compounds 1-4 , this is the first report of their antiproliferative activity against cancer cells. For compound 2 , this is the first report on its bioactivity. To our knowledge, this is the first description of the isolation of bioactive constituents from S. scabripes . |
