The Pregnancy, Arsenic, and Immune Response (PAIR) Study in rural northern Bangladesh.

Autor: Avolio LN; Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., Smith TJS; Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., Navas-Acien A; Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, New York, USA., Kruczynski K; Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., Pisanic N; Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., Randad PR; Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., Detrick B; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Fry RC; Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill Gillings School of Global Public Health, Chapel Hill, North Carolina, USA., van Geen A; Lamont-Doherty Earth Observatory, Columbia University, Palisades, New York, USA., Goessler W; Institute of Chemistry - Analytical Chemistry, University of Graz, Graz, Austria., Karron RA; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., Klein SL; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., Ogburn EL; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., Wills-Karp M; Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., Alland K; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., Ayesha K; JiVitA Maternal and Child Health and Nutrition Research Project, Gaibandha, Bangladesh., Dyer B; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., Islam MT; JiVitA Maternal and Child Health and Nutrition Research Project, Gaibandha, Bangladesh., Oguntade HA; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.; Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, Minnesota, USA., Rahman MH; JiVitA Maternal and Child Health and Nutrition Research Project, Gaibandha, Bangladesh., Ali H; JiVitA Maternal and Child Health and Nutrition Research Project, Gaibandha, Bangladesh., Haque R; JiVitA Maternal and Child Health and Nutrition Research Project, Gaibandha, Bangladesh., Shaikh S; JiVitA Maternal and Child Health and Nutrition Research Project, Gaibandha, Bangladesh., Schulze KJ; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., Muraduzzaman AKM; Institute of Epidemiology, Disease Control, and Research, Dhaka, Bangladesh., Alamgir ASM; Institute of Epidemiology, Disease Control, and Research, Dhaka, Bangladesh., Flora MS; Institute of Epidemiology, Disease Control, and Research, Dhaka, Bangladesh., West KP Jr; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., Labrique AB; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., Heaney CD; Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Jazyk: angličtina
Zdroj: Paediatric and perinatal epidemiology [Paediatr Perinat Epidemiol] 2023 Feb; Vol. 37 (2), pp. 165-178. Date of Electronic Publication: 2023 Feb 09.
DOI: 10.1111/ppe.12949
Abstrakt: Background: Arsenic exposure and micronutrient deficiencies may alter immune reactivity to influenza vaccination in pregnant women, transplacental transfer of maternal antibodies to the foetus, and maternal and infant acute morbidity.
Objectives: The Pregnancy, Arsenic, and Immune Response (PAIR) Study was designed to assess whether arsenic exposure and micronutrient deficiencies alter maternal and newborn immunity and acute morbidity following maternal seasonal influenza vaccination during pregnancy.
Population: The PAIR Study recruited pregnant women across a large rural study area in Gaibandha District, northern Bangladesh, 2018-2019.
Design: Prospective, longitudinal pregnancy and birth cohort.
Methods: We conducted home visits to enrol pregnant women in the late first or early second trimester (11-17 weeks of gestational age). Women received a quadrivalent seasonal inactivated influenza vaccine at enrolment. Follow-up included up to 13 visits between enrolment and 3 months postpartum. Arsenic was measured in drinking water and maternal urine. Micronutrient deficiencies were assessed using plasma biomarkers. Vaccine-specific antibody titres were measured in maternal and infant serum. Weekly telephone surveillance ascertained acute morbidity symptoms in women and infants.
Preliminary Results: We enrolled 784 pregnant women between October 2018 and March 2019. Of 784 women who enrolled, 736 (93.9%) delivered live births and 551 (70.3%) completed follow-up visits to 3 months postpartum. Arsenic was detected (≥0.02 μg/L) in 99.7% of water specimens collected from participants at enrolment. The medians (interquartile ranges) of water and urinary arsenic at enrolment were 5.1 (0.5, 25.1) μg/L and 33.1 (19.6, 56.5) μg/L, respectively. Water and urinary arsenic were strongly correlated (Spearman's ⍴ = 0.72) among women with water arsenic ≥ median but weakly correlated (⍴ = 0.17) among women with water arsenic < median.
Conclusions: The PAIR Study is well positioned to examine the effects of low-moderate arsenic exposure and micronutrient deficiencies on immune outcomes in women and infants.
Registration: NCT03930017.
(© 2023 The Authors. Paediatric and Perinatal Epidemiology published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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