Polymorphisms in hormonal-related genes might be associated with variations in permanent tooth crown size.

Autor: Gerber JT; School of Health Sciences, Positivo University, Curitiba, Brazil., Weiss SG; School of Health Sciences, Positivo University, Curitiba, Brazil., Mijolaro LV; School of Health Sciences, Positivo University, Curitiba, Brazil., Silva CS; School of Health Sciences, Positivo University, Curitiba, Brazil., Petinati MFP; School of Health Sciences, Positivo University, Curitiba, Brazil., Meger MN; School of Health Sciences, Positivo University, Curitiba, Brazil., Honório HM; Department of Pediatric Dentistry, Orthodontics and Public Health, Bauru School of Dentistry - University of São Paulo, Bauru, Brazil., Rebellato NLB; Department of Stomatology, School of Dentistry, Federal University of Parana, Curitiba, Brazil., Sebastiani AM; Department of Stomatology, School of Dentistry, Federal University of Parana, Curitiba, Brazil., Küchler EC; Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Avenida do Café s/n - Campus da USP, Ribeirão Preto, Brazil., Scariot R; Department of Stomatology, School of Dentistry, Federal University of Parana, Curitiba, Brazil.
Jazyk: angličtina
Zdroj: Orthodontics & craniofacial research [Orthod Craniofac Res] 2023 Nov; Vol. 26 (4), pp. 539-545. Date of Electronic Publication: 2023 Mar 07.
DOI: 10.1111/ocr.12638
Abstrakt: Background: The variability in tooth crown size (TCS) is influenced by genetic factors and might be regulated by the difference in hormonal response.
Materials and Methods: This study aimed to evaluate the association between variations in TCS of permanent teeth with associated factors and genetic polymorphisms in hormonal-related genes (ESR1, ESR2 and PTH). This cross-sectional study involved dental casts from 86 individuals of both sexes. Dental casts were used to determine the maximum TCS of all fully erupted permanent teeth (except third molars) in the mesiodistal (MD) and buccolingual (BL) dimensions. Data such as sex, ethnicity, dental group (incisor, canine, premolar and molar), dental arch (upper and lower) and genetic polymorphisms of hormonal-related genes were used. The DNA from each patient was collected to evaluate the genetic polymorphisms in ESR1 (rs2234693 and rs9340799), ESR2 (rs1256049 and rs4986938) and PTH (rs694, rs6256 and rs307247) through real-time PCR. The data were submitted to statistical analysis with a significance level of 0.05.
Results: In the MD dimension, the sex, dental group and dental arch were associated with variation in TCS (P < .05). In the BL dimension, the sex, dental group, dental arch and polymorphism in rs694 and rs307247 were associated with variation in TCS.
Conclusions: In short, this study suggests that genetic polymorphisms of PTH are associated with variations in the BL TCS of permanent human teeth.
(© 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
Externí odkaz: