Evaluation of Xpert Carba-R for detecting carbapenemase-producing organisms in South Africa.

Autor: Duze ST; Department of Clinical Microbiology and Infectious Diseases, Faculty of Health Sciences, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa., Thomas T; Department of Clinical Microbiology and Infectious Diseases, Faculty of Health Sciences, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa.; Infection Control Services Laboratory, National Health Laboratory Services, Charlotte Maxeke Academic Hospital, Johannesburg, South Africa., Pelego T; Infection Control Services Laboratory, National Health Laboratory Services, Charlotte Maxeke Academic Hospital, Johannesburg, South Africa., Jallow S; Department of Clinical Microbiology and Infectious Diseases, Faculty of Health Sciences, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa.; Centre for Healthcare-Associated Infections, Antimicrobial Resistance and Mycoses, National Institute for Communicable Diseases, Johannesburg, South Africa., Perovic O; Department of Clinical Microbiology and Infectious Diseases, Faculty of Health Sciences, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa.; Centre for Healthcare-Associated Infections, Antimicrobial Resistance and Mycoses, National Institute for Communicable Diseases, Johannesburg, South Africa., Duse A; Department of Clinical Microbiology and Infectious Diseases, Faculty of Health Sciences, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa.; Infection Control Services Laboratory, National Health Laboratory Services, Charlotte Maxeke Academic Hospital, Johannesburg, South Africa.
Jazyk: angličtina
Zdroj: African journal of laboratory medicine [Afr J Lab Med] 2023 Jan 05; Vol. 12 (1), pp. 1898. Date of Electronic Publication: 2023 Jan 05 (Print Publication: 2023).
DOI: 10.4102/ajlm.v12i1.1898
Abstrakt: This study evaluated the performance of the Xpert Carba-R assay for detecting the five common carbapenemases in carbapenemase-producing organisms in Johannesburg, South Africa between April 2021 and September 2021. The assay demonstrated 98% sensitivity and 97% specificity. It was also able to detect all the carbapenemases in double carbapenemase producers, as well as carbapenemases in non-fermenter organisms. The Xpert Carba-R assay, therefore, allows the rapid (< 1 h) and accurate identification of the common carbapenemases in pure bacterial cultures and rectal swabs. This assay can aid in the timeous institution of appropriate treatment and infection prevention and control measures.
Competing Interests: The authors declare that they have no financial or personal relationships that may have inappropriately influenced them in writing this article.
(© 2023. The Authors.)
Databáze: MEDLINE
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