Novel strategies in nephrology: what to expect from the future?

Autor: Copur S; Department of Medicine, Koc University School of Medicine, Istanbul, Turkey., Tanriover C; Department of Medicine, Koc University School of Medicine, Istanbul, Turkey., Yavuz F; Department of Medicine, Koc University School of Medicine, Istanbul, Turkey., Soler MJ; Department of Nephrology, Vall d'Hebron University Hospital, Universitat Autònoma de Barcelona, Spain.; Nephrology and Kidney Transplant Research Group, Vall d'Hebron Research Institute (VHIR), Barcelona, Spain., Ortiz A; Department of Medicine, Universidad Autonoma de Madrid and IIS-Fundacion Jimenez Diaz, Madrid, Spain., Covic A; Nephrology Clinic, Dialysis and Renal Transplant Center, 'C.I. PARHON' University Hospital, and 'Grigore T. Popa' University of Medicine, Iasi, Romania., Kanbay M; Department of Medicine, Division of Nephrology, Koc University School of Medicine, Istanbul, Turkey.
Jazyk: angličtina
Zdroj: Clinical kidney journal [Clin Kidney J] 2022 Sep 20; Vol. 16 (2), pp. 230-244. Date of Electronic Publication: 2022 Sep 20 (Print Publication: 2023).
DOI: 10.1093/ckj/sfac212
Abstrakt: Chronic kidney disease (CKD) will become the fifth global case of death by 2040. Its largest impact is on premature mortality but the number of persons with kidney failure requiring renal replacement therapy (RRT) is also increasing dramatically. Current RRT is suboptimal due to the shortage of kidney donors and dismal outcomes associated with both hemodialysis and peritoneal dialysis. Kidney care needs a revolution. In this review, we provide an update on emerging knowledge and technologies that will allow an earlier diagnosis of CKD, addressing the current so-called blind spot (e.g. imaging and biomarkers), and improve renal replacement therapies (wearable artificial kidneys, xenotransplantation, stem cell-derived therapies, bioengineered and bio-artificial kidneys).
(© The Author(s) 2022. Published by Oxford University Press on behalf of the ERA.)
Databáze: MEDLINE
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