Incidence and mortality from malignant mesothelioma 1982-2020 and relationship with asbestos exposure: the Australian Mesothelioma Registry.

Autor:	Walker-Bone K; Monash Centre for Occupational and Environmental Health, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia Karen.Walker-Bone@Monash.edu.; MRC Versus Arthritis Centre for Musculoskeletal Health and Work, University of Southampton, Southampton, UK., Benke G; Monash Centre for Occupational and Environmental Health, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia., MacFarlane E; Monash Centre for Occupational and Environmental Health, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia., Klebe S; South Australia Pathology, Flinders Institute, Adelaide, Western Australia, Australia.; Asbestos Diseases Research Institute, Concord, New South Wales, Australia., Takahashi K; Asbestos Diseases Research Institute, Concord, New South Wales, Australia.; The University of Western Australia, Perth, Western Australia, Australia., Brims F; Curtin Medical School, Curtin University - Perth City Campus, Perth, Western Australia, Australia.; Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia., Sim MR; Monash Centre for Occupational and Environmental Health, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia., Driscoll TR; School of Public Health, University of Sydney, Sydney, New South Wales, Australia.
Jazyk:	angličtina
Zdroj:	Occupational and environmental medicine [Occup Environ Med] 2023 Apr; Vol. 80 (4), pp. 186-191. Date of Electronic Publication: 2023 Feb 08.
DOI:	10.1136/oemed-2022-108669
Abstrakt:	Objectives: Malignant mesothelioma is an uncommon cancer associated with asbestos exposure, predominantly occupational. Asbestos has been banned in Australia since 2003 but mesothelioma has a long latency and incident cases continue to present. The Australian Mesothelioma Registry was incepted to collect systematic data about incidence and mortality alongside asbestos exposure. Methods: Benefiting from the Australian national system of cancer notification, all incident cases of mesothelioma in all states and territories are fast-tracked and notified regularly. Notified patients are contacted asking for consent to collect exposure information, initially by postal questionnaire and subsequently by telephone interview. Age-standardised annual incidence rates and mortality rates were calculated. Asbestos exposure was categorised as occupational, non-occupational, neither or, both; and as low, or high, probability of exposure. Results: Mesothelioma incidence appears to have peaked. The age-standardised incidence rates have declined steadily since the early 2000s (peaking in males at 5.9/100 000 and in all-persons at 3.2/100 000), driven by rates in males, who comprise the majority of diagnosed cases. Rates in women have remained fairly stable since that time. Age-standardised mortality rates have followed similar trends. Mesothelioma remains the most common in those aged over 80 years. Nearly all (94%) cases were linked with asbestos exposure (78% occupational in men; 6.8% in women). Conclusions: With effective control of occupational asbestos use, the decline in age-standardised incidence and death rates has occurred. Incidence rates among women, in whom occupational asbestos exposure is rarely detectable, remain unchanged, pointing to the role of household and /or environmental asbestos exposure. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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