A material-sparing simplified buoyancy method for determining the true density of solids.

Autor: Goldenberg M; GoldenBiotech, LLC, 2626 Lavery Court, Unit 307, Newbury Park, CA 91320, USA. Electronic address: info@goldenbiotechlab.com., Vreeman G; Pharmaceutical Materials Science and Engineering Laboratory, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA., Sun DJ; Pharmaceutical Materials Science and Engineering Laboratory, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA., Moffit M; GoldenBiotech, LLC, 2626 Lavery Court, Unit 307, Newbury Park, CA 91320, USA., Li M; GoldenBiotech, LLC, 2626 Lavery Court, Unit 307, Newbury Park, CA 91320, USA., Zernik M; GoldenBiotech, LLC, 2626 Lavery Court, Unit 307, Newbury Park, CA 91320, USA., Ahuja S; GoldenBiotech, LLC, 2626 Lavery Court, Unit 307, Newbury Park, CA 91320, USA., Kim Y; GoldenBiotech, LLC, 2626 Lavery Court, Unit 307, Newbury Park, CA 91320, USA., Semin D; GoldenBiotech, LLC, 2626 Lavery Court, Unit 307, Newbury Park, CA 91320, USA., Sun CC; Pharmaceutical Materials Science and Engineering Laboratory, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: sunx0053@umn.edu.
Jazyk: angličtina
Zdroj: International journal of pharmaceutics [Int J Pharm] 2023 Mar 25; Vol. 635, pp. 122694. Date of Electronic Publication: 2023 Feb 07.
DOI: 10.1016/j.ijpharm.2023.122694
Abstrakt: True density is an important physical property of powdered materials, especially in the context of powder compaction. Currently available methods for true density determination either require a significant amount of materials or are laborious. Hence, a material-sparing and efficient method for true density determination is of value. In this work, we detail a simplified buoyancy-based method capable of fast determination of true density with accuracy comparable to helium pycnometry. This miniaturized method only uses a few milligrams of a powder with data collection process expedited by centrifugation in a laboratory centrifuge. This method can be easily adapted in a laboratory since determination of true density only requires a balance, a micropipette, a laboratory centrifuge, and standard stock liquids of low and high densities. Hence, it is a useful addition to the materials characterization tool kit critical for pharmaceutical formulation development.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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