Skin microvascular reactivity in patients with diabetic retinopathy.

Autor: Glazkov AA; Moscow Regional Research and Clinical Institute ('MONIKI'), 61/2 Shchepkina street, Moscow 129110, Russian Federation., Krasulina KA; Moscow Regional Research and Clinical Institute ('MONIKI'), 61/2 Shchepkina street, Moscow 129110, Russian Federation. Electronic address: krasulinaka@gmail.com., Glazkova PA; Moscow Regional Research and Clinical Institute ('MONIKI'), 61/2 Shchepkina street, Moscow 129110, Russian Federation., Kovaleva YA; Moscow Regional Research and Clinical Institute ('MONIKI'), 61/2 Shchepkina street, Moscow 129110, Russian Federation., Bardeeva JN; Moscow Regional Research and Clinical Institute ('MONIKI'), 61/2 Shchepkina street, Moscow 129110, Russian Federation., Kulikov DA; Moscow Region State University, 24 Very Voloshinoy street, Mytishchi 141014, Russian Federation; Federal Scientific State Budgetary Institution 'N.A. Semashko National Research Institute of Public Health', 12-1 Vorontsovo Pole street, Moscow 105064, Russian Federation.
Jazyk: angličtina
Zdroj: Microvascular research [Microvasc Res] 2023 May; Vol. 147, pp. 104501. Date of Electronic Publication: 2023 Feb 06.
DOI: 10.1016/j.mvr.2023.104501
Abstrakt: Aims: Early detection of microangiopathic complications of diabetes mellitus (DM) is necessary to analyze the patient's condition and prevent disease progression. The study was aimed to investigate the relationship between the presence of retinopathy and decreased reactivity of the microcirculatory bed in patients with diabetes.
Methods: The study involved 130 subjects: healthy volunteers (n = 48), DM patients without retinopathy (n = 53) and with retinopathy (n = 29). Skin microvascular reactivity was assessed on the forearm using laser Doppler flowmetry with a local heating test combined with occlusion.
Results: The slope of local thermal hyperemia curve (Slope-120) and other parameters of microvascular reactivity showed difference in pairwise comparisons between the groups. Slope-120 had the highest sensitivity (0.759) and specificity (0.717) in detection of diabetic retinopathy. The decrease of Slope-120 was associated with retinopathy (odds ratio (OR) - 8.3 (2.9-24.1), p < 0.001), even after adjusting for other factors (OR - 11.0 (1.6-77.2), p = 0.016).
Conclusions: Thus, assessment of skin microvascular reactivity may be a useful test for detecting signs of microangiopathic complications and for screening patients in risk group. Decreased microvascular reactivity has been shown to be prospective as an independent indicator of retinopathy in type 1 DM.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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