Cost and Prescriber and Patient Characteristics of Cenegermin Use in the Medicare Population.

Autor: Dai X; From the Department of Ophthalmology, Wilmer Eye Institute (X.D., A.J., S.K., F.R., F.W.), Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Jensen A; From the Department of Ophthalmology, Wilmer Eye Institute (X.D., A.J., S.K., F.R., F.W.), Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Dun C; Department of Surgery (C.D.), Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Karakus S; From the Department of Ophthalmology, Wilmer Eye Institute (X.D., A.J., S.K., F.R., F.W.), Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Rajaii F; From the Department of Ophthalmology, Wilmer Eye Institute (X.D., A.J., S.K., F.R., F.W.), Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Woreta F; From the Department of Ophthalmology, Wilmer Eye Institute (X.D., A.J., S.K., F.R., F.W.), Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Electronic address: fworeta1@jhmi.edu.
Jazyk: angličtina
Zdroj: American journal of ophthalmology [Am J Ophthalmol] 2023 Jun; Vol. 250, pp. 12-19. Date of Electronic Publication: 2023 Feb 06.
DOI: 10.1016/j.ajo.2023.01.025
Abstrakt: Purpose: To assess the cost and prescriber and patient characteristics associated with the early use of cenegermin (OXERVATE) after its approval among Medicare beneficiaries to better define resource use and areas for improvement in the treatment of neurotrophic keratopathy.
Design: Retrospective, cross-sectional study.
Methods: Medicare Part D claims data of all cenegermin prescriptions from January 1, 2019, to December 31, 2020, were identified using its National Drug Code. Patients younger than 65 years and those with missing demographic characteristics were excluded. Information on patient and prescriber demographic characteristics, quantity of cenegermin prescription, gross drug costs, and patient out-of-pocket costs were extracted from each claim.
Results: In 2019-2020, a total of 2410 Medicare beneficiaries aged 65 years or older were prescribed cenegermin. The mean (standard deviation [SD]) age of these patients was 77.3 (7.6) years. Most patients were female (63.6%), White (87.3%), and lived in urban areas (86.9%). The majority (72%) received a standard 8-week course. A total of 1025 clinicians prescribed cenegermin. Most were male (68.2%), in an urban setting (90.8%). The median (interquartile range [IQR]) duration of cenegermin therapy prescribed per patient by each clinician was 8 (7.5-8) weeks. Total gross drug cost of all cenegermin therapy over the study period was $287 million. Median (IQR) out-of-pocket patient cost was $5791 (180-7179).
Conclusions: Despite the clinical benefits of cenegermin therapy, the associated significant cost warrants further analysis of its cost-effectiveness in patient care, especially in comparison with alternative novel management options.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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