The role of granulocyte-macrophage colony-stimulating factor in head and neck cancer.

Autor: Lopes-Santos G; Department of Surgery, Stomatology, Pathology, and Radiology, Area of Pathology, Bauru School of Dentistry, University of São Paulo, Alameda Octávio Pinheiro Brisolla, 9-75, Bauru, São Paulo 17012-901, Brazil. Electronic address: glsantos@usp.br., Tjioe KC; Georgia Cancer Center, Augusta University, 1410 Laney Walker Blvd., CN2236B, Augusta, GA 30912, USA. Electronic address: ktjioe@augusta.edu., Magalhaes MAO; Faculty of Dentistry, University of Toronto, 124 Edward St, Toronto, ON M5G 1×3, Canada. Electronic address: marco.magalhaes@dentistry.utoronto.ca., Oliveira DT; Department of Surgery, Stomatology, Pathology, and Radiology, Area of Pathology, Bauru School of Dentistry, University of São Paulo, Alameda Octávio Pinheiro Brisolla, 9-75, Bauru, São Paulo 17012-901, Brazil. Electronic address: denisetostes@usp.br.
Jazyk: angličtina
Zdroj: Archives of oral biology [Arch Oral Biol] 2023 Mar; Vol. 147, pp. 105641. Date of Electronic Publication: 2023 Feb 03.
DOI: 10.1016/j.archoralbio.2023.105641
Abstrakt: Objective: To review the molecular mechanisms and biological roles of granulocyte-macrophage colony-stimulating factor (GM-CSF) in head and neck squamous cell carcinoma, highlighting its potential clinical applications.
Design: The search terms "granulocyte-macrophage colony-stimulating factor", "GM-CSF", "CSF2″ and "head and neck squamous cell carcinoma" or "head and neck cancer" were queried in the PubMed/MEDLINE and Scopus databases.
Results: Despite of being a widely expressed cytokine, the number of studies investigating the specific roles of GM-CSF in head and neck cancer was limited. Most of them investigated GM-CSF in conjunction with other cytokines. When studied alone, conflicting findings were observed in head and neck squamous cell carcinoma. GM-CSF has been shown to induce angiogenesis and local tumor invasion. Additionally, it has also been implicated in immune evasion. On the other hand, GM-CSF stimulated the differentiation of dendritic cells, which are responsible for presenting tumor antigens, and for the regulation of T cell function. Even with these paradoxical effects, there are few studies investigating the potential of GM-CSF as adjuvant therapy in head and neck cancer.
Conclusion: The effects of GM-CSF in head and neck cancer may be pro- or antitumor. Understanding how one arm and not the other is activated is essential to assess the applicability and the safety of this cytokine as a therapeutic agent.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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