Toward defining the role of the synovium in mitigating normal articular cartilage wear and tear.

Autor: Pellicore MJ; Department of Biomedical Engineering, Columbia University, New York, NY, USA., Gangi LR; Department of Biomedical Engineering, Columbia University, New York, NY, USA., Murphy LA; Department of Biomedical Engineering, Columbia University, New York, NY, USA., Lee AJ; Department of Biomedical Engineering, Columbia University, New York, NY, USA., Jacobsen T; Department of Biomedical Engineering, Columbia University, New York, NY, USA., Kenawy HM; Department of Biomedical Engineering, Columbia University, New York, NY, USA., Shah RP; Department of Orthopedic Surgery, Columbia University, New York, NY, USA., Chahine NO; Department of Biomedical Engineering, Columbia University, New York, NY, USA; Department of Orthopedic Surgery, Columbia University, New York, NY, USA., Ateshian GA; Department of Orthopedic Surgery, Columbia University, New York, NY, USA; Department of Mechanical Engineering, Columbia University, New York, NY, USA., Hung CT; Department of Biomedical Engineering, Columbia University, New York, NY, USA; Department of Orthopedic Surgery, Columbia University, New York, NY, USA. Electronic address: cth6@columbia.edu.
Jazyk: angličtina
Zdroj: Journal of biomechanics [J Biomech] 2023 Feb; Vol. 148, pp. 111472. Date of Electronic Publication: 2023 Jan 26.
DOI: 10.1016/j.jbiomech.2023.111472
Abstrakt: Cartilage repair has been studied extensively in the context of injury and disease, but the joint's management of regular sub-injurious damage to cartilage, or 'wear and tear,' which occurs due to normal activity, is poorly understood. We hypothesize that this cartilage maintenance is mediated in part by cells derived from the synovium that migrate to the worn articular surface. Here, we demonstrate in vitro that the early steps required for such a process can occur. First, we show that under physiologic mechanical loads, chondrocyte death occurs in the cartilage superficial zone along with changes to the cartilage surface topography. Second, we show that synoviocytes are released from the synovial lining under physiologic loads and attach to worn cartilage. Third, we show that synoviocytes parachuted onto a simulated or native cartilage surface will modify their behavior. Specifically, we show that synoviocyte interactions with chondrocytes lead to changes in synoviocyte mechanosensitivity, and we demonstrate that cartilage-attached synoviocytes can express COL2A1, a hallmark of the chondrogenic phenotype. Our findings suggest that synoviocyte-mediated repair of cartilage 'wear and tear' as a component of joint homeostasis is feasible and is deserving of future study.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: