Anti-merozoite antibodies induce natural killer cell effector function and are associated with immunity against malaria.

Autor: Odera DO; Centre of Infectious Diseases, Heidelberg University Hospital, Heidelberg, Germany.; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya., Tuju J; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya., Mwai K; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya.; Epidemiology and Biostatistics Division, School of Public Health, University of the Witwatersrand, Johannesburg, South Africa., Nkumama IN; Centre of Infectious Diseases, Heidelberg University Hospital, Heidelberg, Germany., Fürle K; Centre of Infectious Diseases, Heidelberg University Hospital, Heidelberg, Germany., Chege T; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya., Kimathi R; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya., Diehl S; Centre of Infectious Diseases, Heidelberg University Hospital, Heidelberg, Germany., Musasia FK; Centre of Infectious Diseases, Heidelberg University Hospital, Heidelberg, Germany., Rosenkranz M; Centre of Infectious Diseases, Heidelberg University Hospital, Heidelberg, Germany., Njuguna P; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya., Hamaluba M; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya., Kapulu MC; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya., Frank R; Centre of Infectious Diseases, Heidelberg University Hospital, Heidelberg, Germany., Osier FHA; Centre of Infectious Diseases, Heidelberg University Hospital, Heidelberg, Germany.; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya.; Department of Life Sciences, Imperial College London, UK., Abdi AI, Chi PC, de Laurent Z, Jao I, Kamuya D, Kamuyu G, Makale J, Murungi L, Musyoki J, Muthui M, Mwacharo J, Kariuki S, Mwanga D, Mwongeli J, Ndungu F, Njue M, Nyangweso G, Kimani D, Ngoi JM, Musembi J, Ngoto O, Otieno E, Ooko M, Shangala J, Wambua J, Mohammed KS, Omuoyo D, Mosobo M, Kibinge N, Kinyanjui S, Bejon P, Lowe B, Marsh K, Marsh V, Abebe Y, Billingsley PF, Sim BKL, Hoffman SL, James ER, Richie TL, Audi A, Olewe F, Oloo J, Ongecha J, Ongas MO, Koskei N, Bull PC, Hodgson SH, Kivisi C, Imwong M, Murphy SC, Ogutu B, Tarning J, Winterberg M, Williams TN
Jazyk: angličtina
Zdroj: Science translational medicine [Sci Transl Med] 2023 Feb 08; Vol. 15 (682), pp. eabn5993. Date of Electronic Publication: 2023 Feb 08.
DOI: 10.1126/scitranslmed.abn5993
Abstrakt: Natural killer (NK) cells are potent immune effectors that can be activated via antibody-mediated Fc receptor engagement. Using multiparameter flow cytometry, we found that NK cells degranulate and release IFN-γ upon stimulation with antibody-opsonized Plasmodium falciparum merozoites. Antibody-dependent NK (Ab-NK) activity was largely strain transcending and enhanced invasion inhibition into erythrocytes. Ab-NK was associated with the successful control of parasitemia after experimental malaria challenge in African adults. In an independent cohort study in children, Ab-NK increased with age, was boosted by concurrent P. falciparum infections, and was associated with a lower risk of clinical episodes of malaria. Nine of the 14 vaccine candidates tested induced Ab-NK, including some less well-characterized antigens: P41, P113, MSP11, RHOPH3, and Pf _11363200. These data highlight an important role of Ab-NK activity in immunity against malaria and provide a potential mechanism for evaluating vaccine candidates.
Databáze: MEDLINE